TY - JOUR
T1 - Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19
AU - Jeyaraman, Madhan
AU - John, Albin
AU - Koshy, Santhosh
AU - Ranjan, Rajni
AU - Anudeep, Talagavadi Channaiah
AU - Jain, Rashmi
AU - Swati, Kumari
AU - Jha, Niraj Kumar
AU - Sharma, Ankur
AU - Kesari, Kavindra Kumar
AU - Prakash, Anand
AU - Nand, Parma
AU - Jha, Saurabh Kumar
AU - Reddy, P. Hemachandra
PY - 2021/2/1
Y1 - 2021/2/1
N2 - The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pandemic on the 11th of March 2020. Individuals with underlying systemic disorders have reported complications, such as cytokine storms, when infected with the virus. As the number of positive cases and the death toll across the globe continue to rise, various researchers have turned to cell based therapy using stem cells to combat COVID-19. The field of stem cells and regenerative medicine has provided a paradigm shift in treating a disease with minimally invasive techniques that provides maximal clinical and functional outcome for patients. With the available evidence of immunomodulatory and immune-privilege actions, mesenchymal stem cells (MSCs) can repair, regenerate and remodulate the native homeostasis of pulmonary parenchyma with improved pulmonary compliance. This article revolves around the usage of novel MSCs therapy for combating COVID-19.
AB - The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pandemic on the 11th of March 2020. Individuals with underlying systemic disorders have reported complications, such as cytokine storms, when infected with the virus. As the number of positive cases and the death toll across the globe continue to rise, various researchers have turned to cell based therapy using stem cells to combat COVID-19. The field of stem cells and regenerative medicine has provided a paradigm shift in treating a disease with minimally invasive techniques that provides maximal clinical and functional outcome for patients. With the available evidence of immunomodulatory and immune-privilege actions, mesenchymal stem cells (MSCs) can repair, regenerate and remodulate the native homeostasis of pulmonary parenchyma with improved pulmonary compliance. This article revolves around the usage of novel MSCs therapy for combating COVID-19.
KW - Coronavirus
KW - COVID-19
KW - Mesenchymal stem cells
KW - WHO
UR - http://www.scopus.com/inward/record.url?scp=85097161969&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2020.166014
DO - 10.1016/j.bbadis.2020.166014
M3 - Review Article
C2 - 33232817
AN - SCOPUS:85097161969
VL - 1867
JO - BIOCHIMICA ET BIOPHYSICA ACTA: MOLECULAR BASIS OF DISEASE
JF - BIOCHIMICA ET BIOPHYSICA ACTA: MOLECULAR BASIS OF DISEASE
SN - 0925-4439
IS - 2
M1 - 166014
ER -
