fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG
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fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG. / Lin, Fa-Hsuan; Witzel, Thomas; Raij, Tommi; Ahveninen, Jyrki; Tsai, Kevin Wen-Kai; Chu, Yin-Hua; Chang, Wei-Tang; Nummenmaa, Aapo; Polimeni, Jonathan R.; Kuo, Wen-Jui; Hsieh, Jen-Chuen; Rosen, Bruce R.; Belliveau, John W.
In: NeuroImage, Vol. 78, 09.2013, p. 372-384.Research output: Contribution to journal › Article › Scientific › peer-review
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T1 - fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG
AU - Lin, Fa-Hsuan
AU - Witzel, Thomas
AU - Raij, Tommi
AU - Ahveninen, Jyrki
AU - Tsai, Kevin Wen-Kai
AU - Chu, Yin-Hua
AU - Chang, Wei-Tang
AU - Nummenmaa, Aapo
AU - Polimeni, Jonathan R.
AU - Kuo, Wen-Jui
AU - Hsieh, Jen-Chuen
AU - Rosen, Bruce R.
AU - Belliveau, John W.
PY - 2013/9
Y1 - 2013/9
N2 - Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.
AB - Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.
KW - Neurovascular coupling
KW - Hemodynamics
KW - Neuronal timing
KW - Inverse imaging
KW - Latency
KW - BOLD
KW - TIME-RESOLVED FMRI
KW - SURFACE-BASED ANALYSIS
KW - EVENT-RELATED FMRI
KW - FUNCTIONAL MRI
KW - VISUAL-CORTEX
KW - CORTICAL SURFACE
KW - SENSORY STIMULATION
KW - COORDINATE SYSTEM
KW - MENTAL ROTATION
KW - SIGNALS
U2 - 10.1016/j.neuroimage.2013.04.017
DO - 10.1016/j.neuroimage.2013.04.017
M3 - Article
VL - 78
SP - 372
EP - 384
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -
ID: 9682553