fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG

Fa-Hsuan Lin; Thomas Witzel; Tommi Raij; Jyrki Ahveninen; Kevin Wen-Kai Tsai; Yin-Hua Chu; Wei-Tang Chang; Aapo Nummenmaa; Jonathan R. Polimeni; Wen-Jui Kuo; Jen-Chuen Hsieh; Bruce R. Rosen; John W. Belliveau

doi:10.1016/j.neuroimage.2013.04.017

fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG

Research output: Contribution to journal › Article › Scientific › peer-review

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fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG. / Lin, Fa-Hsuan; Witzel, Thomas; Raij, Tommi; Ahveninen, Jyrki; Tsai, Kevin Wen-Kai; Chu, Yin-Hua; Chang, Wei-Tang; Nummenmaa, Aapo; Polimeni, Jonathan R.; Kuo, Wen-Jui; Hsieh, Jen-Chuen; Rosen, Bruce R.; Belliveau, John W.

In: NeuroImage, Vol. 78, 09.2013, p. 372-384.

Research output: Contribution to journal › Article › Scientific › peer-review

Harvard

Lin, F-H, Witzel, T, Raij, T, Ahveninen, J, Tsai, KW-K, Chu, Y-H, Chang, W-T, Nummenmaa, A, Polimeni, JR, Kuo, W-J, Hsieh, J-C, Rosen, BR & Belliveau, JW 2013, 'fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG', NeuroImage, vol. 78, pp. 372-384. https://doi.org/10.1016/j.neuroimage.2013.04.017

APA

Lin, F-H., Witzel, T., Raij, T., Ahveninen, J., Tsai, K. W-K., Chu, Y-H., ... Belliveau, J. W. (2013). fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG. NeuroImage, 78, 372-384. https://doi.org/10.1016/j.neuroimage.2013.04.017

Vancouver

Lin F-H, Witzel T, Raij T, Ahveninen J, Tsai KW-K, Chu Y-H et al. fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG. NeuroImage. 2013 Sep;78:372-384. https://doi.org/10.1016/j.neuroimage.2013.04.017

Author

Lin, Fa-Hsuan ; Witzel, Thomas ; Raij, Tommi ; Ahveninen, Jyrki ; Tsai, Kevin Wen-Kai ; Chu, Yin-Hua ; Chang, Wei-Tang ; Nummenmaa, Aapo ; Polimeni, Jonathan R. ; Kuo, Wen-Jui ; Hsieh, Jen-Chuen ; Rosen, Bruce R. ; Belliveau, John W. / fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG. In: NeuroImage. 2013 ; Vol. 78. pp. 372-384.

Bibtex - Download

@article{46dbaf63bfe74058a1139d95b034e8c7,

title = "fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG",

abstract = "Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.",

keywords = "Neurovascular coupling, Hemodynamics, Neuronal timing, Inverse imaging, Latency, BOLD, TIME-RESOLVED FMRI, SURFACE-BASED ANALYSIS, EVENT-RELATED FMRI, FUNCTIONAL MRI, VISUAL-CORTEX, CORTICAL SURFACE, SENSORY STIMULATION, COORDINATE SYSTEM, MENTAL ROTATION, SIGNALS",

author = "Fa-Hsuan Lin and Thomas Witzel and Tommi Raij and Jyrki Ahveninen and Tsai, {Kevin Wen-Kai} and Yin-Hua Chu and Wei-Tang Chang and Aapo Nummenmaa and Polimeni, {Jonathan R.} and Wen-Jui Kuo and Jen-Chuen Hsieh and Rosen, {Bruce R.} and Belliveau, {John W.}",

year = "2013",

month = "9",

doi = "10.1016/j.neuroimage.2013.04.017",

language = "English",

volume = "78",

pages = "372--384",

journal = "NeuroImage",

issn = "1053-8119",

}

RIS - Download

TY - JOUR

T1 - fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG

AU - Lin, Fa-Hsuan

AU - Witzel, Thomas

AU - Raij, Tommi

AU - Ahveninen, Jyrki

AU - Tsai, Kevin Wen-Kai

AU - Chu, Yin-Hua

AU - Chang, Wei-Tang

AU - Nummenmaa, Aapo

AU - Polimeni, Jonathan R.

AU - Kuo, Wen-Jui

AU - Hsieh, Jen-Chuen

AU - Rosen, Bruce R.

AU - Belliveau, John W.

PY - 2013/9

Y1 - 2013/9

N2 - Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.

AB - Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.

KW - Neurovascular coupling

KW - Hemodynamics

KW - Neuronal timing

KW - Inverse imaging

KW - Latency

KW - BOLD

KW - TIME-RESOLVED FMRI

KW - SURFACE-BASED ANALYSIS

KW - EVENT-RELATED FMRI

KW - FUNCTIONAL MRI

KW - VISUAL-CORTEX

KW - CORTICAL SURFACE

KW - SENSORY STIMULATION

KW - COORDINATE SYSTEM

KW - MENTAL ROTATION

KW - SIGNALS

U2 - 10.1016/j.neuroimage.2013.04.017

DO - 10.1016/j.neuroimage.2013.04.017

M3 - Article

VL - 78

SP - 372

EP - 384

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

ID: 9682553