fMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG

Fa-Hsuan Lin*, Thomas Witzel, Tommi Raij, Jyrki Ahveninen, Kevin Wen-Kai Tsai, Yin-Hua Chu, Wei-Tang Chang, Aapo Nummenmaa, Jonathan R. Polimeni, Wen-Jui Kuo, Jen-Chuen Hsieh, Bruce R. Rosen, John W. Belliveau

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Abstract

Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100 ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100 ms; all delays >= 400 ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. (C) 2013 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)372-384
Number of pages13
JournalNeuroImage
Volume78
DOIs
Publication statusPublished - Sept 2013
MoE publication typeA1 Journal article-refereed

Keywords

  • Neurovascular coupling
  • Hemodynamics
  • Neuronal timing
  • Inverse imaging
  • Latency
  • BOLD
  • TIME-RESOLVED FMRI
  • SURFACE-BASED ANALYSIS
  • EVENT-RELATED FMRI
  • FUNCTIONAL MRI
  • VISUAL-CORTEX
  • CORTICAL SURFACE
  • SENSORY STIMULATION
  • COORDINATE SYSTEM
  • MENTAL ROTATION
  • SIGNALS

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