Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Henri J. Huttunen
  • J. Matias Palva
  • Laura Lindberg
  • Satu Palva
  • Ville Saarela
  • Elina Karvonen
  • Marja Leena Latvala
  • Johanna Liinamaa
  • Sigrid Booms
  • Eero Castrén
  • Hannu Uusitalo

Research units

  • Herantis Pharma Plc
  • Neuroscience Center
  • University of Helsinki
  • PEDEGO Research Unit
  • University of Oulu
  • Tampere University
  • Tampere University Hospital
  • University of Helsinki

Abstract

Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: −0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (−0.167 logMAR; 95% CI: −0.226 to −0.108; p < 0.001) and placebo (−0.194 logMAR; 95% CI: −0.254 to −0.133; p < 0.001) groups. While this study failed to provide evidence that fluoxetine enhances neuroplasticity, our data support other recent clinical studies suggesting that improvement of vision can be accomplished in adults with amblyopia.

Details

Original languageEnglish
Article number12830
JournalScientific Reports
Volume8
Issue number1
Publication statusPublished - 1 Dec 2018
MoE publication typeA1 Journal article-refereed

ID: 41624479