Flexible Micropillar Electrode Arrays for In Vivo Neural Activity Recordings

Research output: Contribution to journalArticleScientificpeer-review


  • Mingde Du

  • Shouliang Guan
  • Lei Gao
  • Suye Lv
  • Siting Yang
  • Jidong Shi
  • Jinfen Wang
  • Hongbian Li
  • Ying Fang

Research units

  • University of Chinese Academy of Sciences
  • Chinese Academy of Sciences
  • National Center for Nanoscience and Technology Beijing


Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is described based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of a rat cerebral cortex. Moreover, the recording sites of the µPEA consist of protruding micropillars with nanoscale surface roughness that ensure tight interfacing and efficient electrical coupling with the nervous system. As a result, the flexible µPEA allows for in vivo multichannel recordings of epileptiform activity with a high signal-to-noise ratio of 252 ± 35. The ease of preparation, high flexibility, and biocompatibility make the µPEA an attractive tool for in vivo spatiotemporal mapping of neural activity.


Original languageEnglish
Article number1900582
Number of pages7
Issue number20
Early online date1 Jan 2019
Publication statusPublished - 17 May 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • electrocorticography, epilepsy, flexible electronics, neural recording, subdural electrodes

ID: 33510825