Evidence for distinct human auditory cortex regions for sound location versus identity processing

Research output: Contribution to journalArticleScientificpeer-review

Standard

Evidence for distinct human auditory cortex regions for sound location versus identity processing. / Ahveninen, J.; Huang, S.; Nummenmaa, A.; Belliveau, J.W.; Hung, A.Y.; Jaaskelainen, I.P.; Rauschecker, J.P.; Rossi, S.; Tiitinen, H.; Raij, T.

In: Nature Communications, Vol. 4, 2585, 2013, p. 1-8.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Ahveninen, J, Huang, S, Nummenmaa, A, Belliveau, JW, Hung, AY, Jaaskelainen, IP, Rauschecker, JP, Rossi, S, Tiitinen, H & Raij, T 2013, 'Evidence for distinct human auditory cortex regions for sound location versus identity processing' Nature Communications, vol. 4, 2585, pp. 1-8. https://doi.org/10.1038/ncomms3585

APA

Vancouver

Author

Ahveninen, J. ; Huang, S. ; Nummenmaa, A. ; Belliveau, J.W. ; Hung, A.Y. ; Jaaskelainen, I.P. ; Rauschecker, J.P. ; Rossi, S. ; Tiitinen, H. ; Raij, T. / Evidence for distinct human auditory cortex regions for sound location versus identity processing. In: Nature Communications. 2013 ; Vol. 4. pp. 1-8.

Bibtex - Download

@article{742e44b596004e6f9037004ca5742340,
title = "Evidence for distinct human auditory cortex regions for sound location versus identity processing",
abstract = "Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55–145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.",
author = "J. Ahveninen and S. Huang and A. Nummenmaa and J.W. Belliveau and A.Y. Hung and I.P. Jaaskelainen and J.P. Rauschecker and S. Rossi and H. Tiitinen and T. Raij",
year = "2013",
doi = "10.1038/ncomms3585",
language = "English",
volume = "4",
pages = "1--8",
journal = "Nature Communications",
issn = "2041-1723",

}

RIS - Download

TY - JOUR

T1 - Evidence for distinct human auditory cortex regions for sound location versus identity processing

AU - Ahveninen, J.

AU - Huang, S.

AU - Nummenmaa, A.

AU - Belliveau, J.W.

AU - Hung, A.Y.

AU - Jaaskelainen, I.P.

AU - Rauschecker, J.P.

AU - Rossi, S.

AU - Tiitinen, H.

AU - Raij, T.

PY - 2013

Y1 - 2013

N2 - Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55–145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.

AB - Neurophysiological animal models suggest that anterior auditory cortex (AC) areas process sound identity information, whereas posterior ACs specialize in sound location processing. In humans, inconsistent neuroimaging results and insufficient causal evidence have challenged the existence of such parallel AC organization. Here we transiently inhibit bilateral anterior or posterior AC areas using MRI-guided paired-pulse transcranial magnetic stimulation (TMS) while subjects listen to Reference/Probe sound pairs and perform either sound location or identity discrimination tasks. The targeting of TMS pulses, delivered 55–145 ms after Probes, is confirmed with individual-level cortical electric-field estimates. Our data show that TMS to posterior AC regions delays reaction times (RT) significantly more during sound location than identity discrimination, whereas TMS to anterior AC regions delays RTs significantly more during sound identity than location discrimination. This double dissociation provides direct causal support for parallel processing of sound identity features in anterior AC and sound location in posterior AC.

U2 - 10.1038/ncomms3585

DO - 10.1038/ncomms3585

M3 - Article

VL - 4

SP - 1

EP - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2585

ER -

ID: 842299