Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

Research output: Contribution to journalArticleScientificpeer-review

Standard

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. / Konki, Mikko; Pasumarthy, Kalyan; Malonzo, Maia; Sainio, Annele; Valensisi, Cristina; Söderström, Mirva; Emani, Maheswara Reddy; Stubb, Aki; Närvä, Elisa; Ghimire, Bishwa; Laiho, Asta; Järveläinen, Hannu; Lahesmaa, Riitta; Lähdesmäki, Harri; Hawkins, R. David; Lund, Riikka J.

In: Scientific Reports, Vol. 6, 22190, 25.02.2016.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Konki, M, Pasumarthy, K, Malonzo, M, Sainio, A, Valensisi, C, Söderström, M, Emani, MR, Stubb, A, Närvä, E, Ghimire, B, Laiho, A, Järveläinen, H, Lahesmaa, R, Lähdesmäki, H, Hawkins, RD & Lund, RJ 2016, 'Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells' Scientific Reports, vol. 6, 22190. https://doi.org/10.1038/srep22190

APA

Vancouver

Author

Konki, Mikko ; Pasumarthy, Kalyan ; Malonzo, Maia ; Sainio, Annele ; Valensisi, Cristina ; Söderström, Mirva ; Emani, Maheswara Reddy ; Stubb, Aki ; Närvä, Elisa ; Ghimire, Bishwa ; Laiho, Asta ; Järveläinen, Hannu ; Lahesmaa, Riitta ; Lähdesmäki, Harri ; Hawkins, R. David ; Lund, Riikka J. / Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells. In: Scientific Reports. 2016 ; Vol. 6.

Bibtex - Download

@article{b7d0bcff994b4432b7e93bcb9b38b64d,
title = "Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells",
abstract = "Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.",
keywords = "stem cells, cancer",
author = "Mikko Konki and Kalyan Pasumarthy and Maia Malonzo and Annele Sainio and Cristina Valensisi and Mirva S{\"o}derstr{\"o}m and Emani, {Maheswara Reddy} and Aki Stubb and Elisa N{\"a}rv{\"a} and Bishwa Ghimire and Asta Laiho and Hannu J{\"a}rvel{\"a}inen and Riitta Lahesmaa and Harri L{\"a}hdesm{\"a}ki and Hawkins, {R. David} and Lund, {Riikka J.}",
year = "2016",
month = "2",
day = "25",
doi = "10.1038/srep22190",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",

}

RIS - Download

TY - JOUR

T1 - Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

AU - Konki, Mikko

AU - Pasumarthy, Kalyan

AU - Malonzo, Maia

AU - Sainio, Annele

AU - Valensisi, Cristina

AU - Söderström, Mirva

AU - Emani, Maheswara Reddy

AU - Stubb, Aki

AU - Närvä, Elisa

AU - Ghimire, Bishwa

AU - Laiho, Asta

AU - Järveläinen, Hannu

AU - Lahesmaa, Riitta

AU - Lähdesmäki, Harri

AU - Hawkins, R. David

AU - Lund, Riikka J.

PY - 2016/2/25

Y1 - 2016/2/25

N2 - Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.

AB - Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.

KW - stem cells

KW - cancer

UR - http://www.scopus.com/inward/record.url?scp=84959355302&partnerID=8YFLogxK

U2 - 10.1038/srep22190

DO - 10.1038/srep22190

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 22190

ER -

ID: 1728832