TY - JOUR
T1 - Epigenetic factors in breast cancer therapy
AU - Mathur, Runjhun
AU - Jha, Niraj Kumar
AU - Saini, Gaurav
AU - Jha, Saurabh Kumar
AU - Shukla, Sheo Prasad
AU - Filipejová, Zita
AU - Kesari, Kavindra Kumar
AU - Iqbal, Danish
AU - Nand, Parma
AU - Upadhye, Vijay Jagdish
AU - Jha, Abhimanyu Kumar
AU - Roychoudhury, Shubhadeep
AU - Slama, Petr
N1 - Funding Information:
The authors would like to acknowledge the support from their respective institutes throughout the review writing process.
Publisher Copyright:
Copyright © 2022 Mathur, Jha, Saini, Jha, Shukla, Filipejová, Kesari, Iqbal, Nand, Upadhye, Jha, Roychoudhury and Slama.
PY - 2022/9/23
Y1 - 2022/9/23
N2 - Epigenetic modifications are inherited differences in cellular phenotypes, such as cell gene expression alterations, that occur during somatic cell divisions (also, in rare circumstances, in germ line transmission), but no alterations to the DNA sequence are involved. Histone alterations, polycomb/trithorax associated proteins, short non-coding or short RNAs, long non—coding RNAs (lncRNAs), & DNA methylation are just a few biological processes involved in epigenetic events. These various modifications are intricately linked. The transcriptional potential of genes is closely conditioned by epigenetic control, which is crucial in normal growth and development. Epigenetic mechanisms transmit genomic adaptation to an environment, resulting in a specific phenotype. The purpose of this systematic review is to glance at the roles of Estrogen signalling, polycomb/trithorax associated proteins, DNA methylation in breast cancer progression, as well as epigenetic mechanisms in breast cancer therapy, with an emphasis on functionality, regulatory factors, therapeutic value, and future challenges.
AB - Epigenetic modifications are inherited differences in cellular phenotypes, such as cell gene expression alterations, that occur during somatic cell divisions (also, in rare circumstances, in germ line transmission), but no alterations to the DNA sequence are involved. Histone alterations, polycomb/trithorax associated proteins, short non-coding or short RNAs, long non—coding RNAs (lncRNAs), & DNA methylation are just a few biological processes involved in epigenetic events. These various modifications are intricately linked. The transcriptional potential of genes is closely conditioned by epigenetic control, which is crucial in normal growth and development. Epigenetic mechanisms transmit genomic adaptation to an environment, resulting in a specific phenotype. The purpose of this systematic review is to glance at the roles of Estrogen signalling, polycomb/trithorax associated proteins, DNA methylation in breast cancer progression, as well as epigenetic mechanisms in breast cancer therapy, with an emphasis on functionality, regulatory factors, therapeutic value, and future challenges.
KW - breast
KW - cancer
KW - epigenetics
KW - estrogen
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85140097436&partnerID=8YFLogxK
U2 - 10.3389/fgene.2022.886487
DO - 10.3389/fgene.2022.886487
M3 - Review Article
AN - SCOPUS:85140097436
SN - 1664-8021
VL - 13
SP - 1
EP - 13
JO - Frontiers in Genetics
JF - Frontiers in Genetics
M1 - 886487
ER -
