Enzymatic kinetic resolution of primary allenic alcohols. Application to the total synthesis and stereochemical assignment of striatisporolide A

Research output: Contribution to journalArticle

Researchers

Research units

  • Stockholm University

Abstract

Crude porcine pancreatic lipase was successfully used for the kinetic resolution of axially chiral primary allenic alcohols providing very high enantioselectivities with E values above 200. This simple access to optically active allenes was applied to the total synthesis of the fungal metabolite (−)-striatisporolide A, allowing its unambiguous stereochemical assignment.

Details

Original languageEnglish
Pages (from-to)3379-3381
Number of pages3
JournalORGANIC AND BIOMOLECULAR CHEMISTRY
Volume7
Publication statusPublished - 29 Jun 2009
MoE publication typeA1 Journal article-refereed

    Research areas

  • natural product synthesis, chemoenzymatic, lipase, kinetic resolution, heterocycles, biocatalysis

ID: 11164053