Projects per year
Abstract
Chloroperoxidase from Caldariomyces fumago catalyzes the aerobic oxidative halocyclization of allenic alcohols and carboxylates yielding functionalized furan and pyran heterocycles as valuable synthetic scaffolds. Thanks to an oxidase-initiated redox cascade, simple halide salts – in combination with air and glucose – act as stoichiometric reagents for the in situ generation of reactive halonium species. Under the mild reaction conditions in an aqueous emulsion medium, the stereochemical integrity of diastereoand enantioenriched allenes remains uncompromised and chiral dihydrofurans can be obtained via 5-endo-trig cyclizations with perfect axis-to-centre chirality transfer.
Original language | English |
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Pages (from-to) | 447-452 |
Number of pages | 6 |
Journal | Green Chemistry |
Volume | 19 |
DOIs | |
Publication status | Published - 2017 |
MoE publication type | A1 Journal article-refereed |
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Dive into the research topics of 'Enzymatic halocyclization of allenic alcohols and carboxylates: a biocatalytic entry to functionalized O-heterocycles'. Together they form a unique fingerprint.Projects
- 1 Finished
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Beyond Biosynthesis: Enzymes as Catalysts in Non-natural Synthetic Transformations
Blume, F., Jäger, C., Deska, J., Naapuri, J., Liu, Y. & Kiefer, A.
01/09/2016 → 31/03/2021
Project: Academy of Finland: Other research funding
Equipment
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Bioeconomy Research Infrastructure
Jukka Seppälä (Manager)
School of Chemical EngineeringFacility/equipment: Facility