Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Yujiao Dong; Heli Paukkonen; Wenwen Fang; Eero Kontturi; Timo Laaksonen; Päivi Laaksonen

doi:10.1016/j.ijpharm.2018.06.022

Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Yujiao Dong
, Heli Paukkonen
, Wenwen Fang
, Eero Kontturi
, Timo Laaksonen
, Päivi Laaksonen^*

^*Corresponding author for this work

University of Helsinki
Tampere University of Technology
Aalto University

Research output: Contribution to journal › Article › Scientific › peer-review

22 Citations (Scopus)

259 Downloads (Pure)

Abstract

Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	548
Issue number	1
DOIs	https://doi.org/10.1016/j.ijpharm.2018.06.022
Publication status	Published - 5 Sept 2018
MoE publication type	A1 Journal article-refereed

Funding

The financial support from Academy of Finland (Grant No. 258114 ) as well as the Academy of Finland Center of Excellence Program, especially the Center of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials ( HYBER ) is gratefully acknowledged. This work made use of the facilities at the Aalto University Nanomicroscopy Center (Aalto-NMC) premises.

Keywords

Cellulose hydrogel
Controlled release
Diffusion-limited release
Microcrystalline cellulose

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10.1016/j.ijpharm.2018.06.022

CHEM_Dong-Laaksonen-et al_Entangled and colloidally-2018-IntJPharAccepted author manuscript, 1.28 MBLicence: CC BY-NC-ND

Cite this

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title = "Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release",

abstract = "Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell{\texttrademark} cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell{\texttrademark} was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.",

keywords = "Cellulose hydrogel, Controlled release, Diffusion-limited release, Microcrystalline cellulose",

author = "Yujiao Dong and Heli Paukkonen and Wenwen Fang and Eero Kontturi and Timo Laaksonen and P{\"a}ivi Laaksonen",

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doi = "10.1016/j.ijpharm.2018.06.022",

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T1 - Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

AU - Dong, Yujiao

AU - Paukkonen, Heli

AU - Fang, Wenwen

AU - Kontturi, Eero

AU - Laaksonen, Timo

AU - Laaksonen, Päivi

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

AB - Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

KW - Cellulose hydrogel

KW - Controlled release

KW - Diffusion-limited release

KW - Microcrystalline cellulose

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EP - 119

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1

ER -

Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

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Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Abstract

Funding

Keywords

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Bioeconomy Research Infrastructure

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