Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Yujiao Dong, Heli Paukkonen, Wenwen Fang, Eero Kontturi, Timo Laaksonen, Päivi Laaksonen*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
142 Downloads (Pure)

Abstract

Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume548
Issue number1
DOIs
Publication statusPublished - 5 Sep 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • Cellulose hydrogel
  • Controlled release
  • Diffusion-limited release
  • Microcrystalline cellulose

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