Abstract
In the course of the synthesis of the DEFG ring system of cneorin C 1, we were faced with the task of preparing the furyl substituted allyl alcohol 5 enantioselectively. Several different methods starting from enantioselective zinc-mediated alkylations were attempted, but none of them proved entirely satisfactory. The solution turned out to be enzymatic kinetic resolution through a highly enantioselective (E > 300) acylation in the presence of Candida antarctica lipase A.
Original language | English |
---|---|
Pages (from-to) | 1637-1643 |
Journal | TETRAHEDRON-ASYMMETRY |
Issue number | 15 |
DOIs | |
Publication status | Published - 2004 |
MoE publication type | A1 Journal article-refereed |