Enantioselective Enzymatic Desymmetrization of Prochiral Allenic Diols

Jan Deska, Chicco Manzuna Sapu

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Crude lipase from porcine pancreas acts as a highly efficient biocatalyst in the enantioselective transesterification of prochiral allendiols. Following a simple synthetic protocol, highly functionalized axially chiral allenes are obtained in high yields and excellent enantiopurity
Original languageEnglish
Pages (from-to)9731-9734
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number41
DOIs
Publication statusPublished - 21 Sep 2011
MoE publication typeA1 Journal article-refereed

Keywords

  • allenes
  • axial chirality
  • desymmetrization
  • enzyme catalysis
  • lipases

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