Enantioconvergent Biocatalytic Redox Isomerization

Yuchang Liu, Christian Merten, Jan Deska

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Alcohol dehydrogenases can act as powerful catalysts in the preparation of optically pure γ‐hydroxy‐δ‐lactones by means of an enantioconvergent dynamic redox isomerization of readily available Achmatowicz‐type pyranones. Imitating the traditionally metal‐mediated “borrowing hydrogen” approach to shuffle hydrides across molecular architectures and interconvert functional groups, this chemoinspired and purely biocatalytic interpretation effectively expands the enzymatic toolbox and provides new opportunities in the assembly of multienzyme cascades and tailor‐made cellular factories.
Original languageEnglish
Pages (from-to)12151-12156
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number37
Publication statusPublished - 9 Jul 2018
MoE publication typeA1 Journal article-refereed


  • redoxisomerization
  • biocatalysis
  • heterocycles
  • enantioconvergent
  • asymmetric


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