Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

Andrea Pizzi; Lorenzo Sori; Claudia Pigliacelli; Alfonso Gautieri; Clara Andolina; Greta Bergamaschi; Alessandro Gori; Pierre Panine; Antonio Mattia Grande; Markus B. Linder; Francesca Baldelli Bombelli; Monica Soncini; Pierangelo Metrangolo

doi:10.1002/smll.202200807

Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

Andrea Pizzi, Lorenzo Sori, Claudia Pigliacelli, Alfonso Gautieri, Clara Andolina, Greta Bergamaschi, Alessandro Gori, Pierre Panine, Antonio Mattia Grande, Markus B. Linder, Francesca Baldelli Bombelli, Monica Soncini, Pierangelo Metrangolo

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

102 Downloads (Pure)

Abstract

Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

Original language	English
Article number	2200807
Pages (from-to)	2200807
Number of pages	10
Journal	Small
Volume	18
Issue number	32
Early online date	20 Jun 2022
DOIs	https://doi.org/10.1002/smll.202200807
Publication status	Published - Aug 2022
MoE publication type	A1 Journal article-refereed

Keywords

bromination
elastomers
halogen bonding
peptides
resilin
self-assembly
supramolecular chemistry

Access to Document

10.1002/smll.202200807Licence: CC BY

Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon BrominationFinal published version, 3.31 MBLicence: CC BY

Cite this

Pizzi, A., Sori, L., Pigliacelli, C., Gautieri, A., Andolina, C., Bergamaschi, G., Gori, A., Panine, P., Grande, A. M., Linder, M. B., Baldelli Bombelli, F., Soncini, M., & Metrangolo, P. (2022). Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination. Small, 18(32), 2200807. Article 2200807. https://doi.org/10.1002/smll.202200807

@article{286edcc447054270a8821b62306d7736,

title = "Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination",

abstract = "Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.",

keywords = "bromination, elastomers, halogen bonding, peptides, resilin, self-assembly, supramolecular chemistry",

author = "Andrea Pizzi and Lorenzo Sori and Claudia Pigliacelli and Alfonso Gautieri and Clara Andolina and Greta Bergamaschi and Alessandro Gori and Pierre Panine and Grande, {Antonio Mattia} and Linder, {Markus B.} and {Baldelli Bombelli}, Francesca and Monica Soncini and Pierangelo Metrangolo",

note = "Tallenna OA-artikkeli, kun julkaistu",

year = "2022",

month = aug,

doi = "10.1002/smll.202200807",

language = "English",

volume = "18",

pages = "2200807",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "32",

}

TY - JOUR

T1 - Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

AU - Pizzi, Andrea

AU - Sori, Lorenzo

AU - Pigliacelli, Claudia

AU - Gautieri, Alfonso

AU - Andolina, Clara

AU - Bergamaschi, Greta

AU - Gori, Alessandro

AU - Panine, Pierre

AU - Grande, Antonio Mattia

AU - Linder, Markus B.

AU - Baldelli Bombelli, Francesca

AU - Soncini, Monica

AU - Metrangolo, Pierangelo

N1 - Tallenna OA-artikkeli, kun julkaistu

PY - 2022/8

Y1 - 2022/8

N2 - Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

AB - Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

KW - bromination

KW - elastomers

KW - halogen bonding

KW - peptides

KW - resilin

KW - self-assembly

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=85132176639&partnerID=8YFLogxK

U2 - 10.1002/smll.202200807

DO - 10.1002/smll.202200807

M3 - Article

SN - 1613-6810

VL - 18

SP - 2200807

JO - Small

JF - Small

IS - 32

M1 - 2200807

ER -

Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this