Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

Kati Räisänen, Irma Koivula, Heikki Ilmavirta, Santeri Puranen, Teemu Kallonen, Outi Lyytikäinen, Jari Jalava

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Abstract

In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.

Original languageEnglish
Pages (from-to)1-3
JournalEUROSURVEILLANCE
Volume24
Issue number19
DOIs
Publication statusPublished - 1 May 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • carbapenem
  • ceftazidime-avibactam
  • Klebsiella pneumoniae
  • resistance
  • whole-genome sequencing, KPC-2

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