Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Claudia Pigliacelli; Daniele Maiolo; Nonappa Nonappa; Johannes Haataja; Heinz Amenitsch; Claire Michelet; Paola Sanchez Moreno; Ilaria Tirotta; Pierangelo Metrangolo; Francesca Baldelli Bombelli

doi:10.1002/ange.201710230

Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Claudia Pigliacelli, Daniele Maiolo, Nonappa Nonappa, Johannes Haataja, Heinz Amenitsch, Claire Michelet, Paola Sanchez Moreno, Ilaria Tirotta, Pierangelo Metrangolo, Francesca Baldelli Bombelli

Research output: Contribution to journal › Article › Scientific › peer-review

28 Citations (Scopus)

Abstract

Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin HFBII. Our strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport in water of high loadings of partially fluorinated drug molecules.

Original language	English
Pages (from-to)	16404–16408
Journal	Angewandte Chemie (International Edition)
Volume	129
Issue number	51
Early online date	6 Nov 2017
DOIs	https://doi.org/10.1002/ange.201710230
Publication status	Published - 18 Dec 2017
MoE publication type	A1 Journal article-refereed

Keywords

Self-assembly
Supraparticle
Fluorous
Hydrophobin
Gold nanoparticles

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10.1002/ange.201710230

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Pigliacelli, C., Maiolo, D., Nonappa, N., Haataja, J., Amenitsch, H., Michelet, C., Sanchez Moreno, P., Tirotta, I., Metrangolo, P., & Baldelli Bombelli, F. (2017). Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles. Angewandte Chemie (International Edition) , 129(51), 16404–16408 . https://doi.org/10.1002/ange.201710230

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abstract = "Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin HFBII. Our strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport in water of high loadings of partially fluorinated drug molecules.",

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author = "Claudia Pigliacelli and Daniele Maiolo and Nonappa Nonappa and Johannes Haataja and Heinz Amenitsch and Claire Michelet and {Sanchez Moreno}, Paola and Ilaria Tirotta and Pierangelo Metrangolo and {Baldelli Bombelli}, Francesca",

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Pigliacelli, C, Maiolo, D, Nonappa, N, Haataja, J, Amenitsch, H, Michelet, C, Sanchez Moreno, P, Tirotta, I, Metrangolo, P & Baldelli Bombelli, F 2017, 'Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles', Angewandte Chemie (International Edition) , vol. 129, no. 51, pp. 16404–16408 . https://doi.org/10.1002/ange.201710230

TY - JOUR

T1 - Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

AU - Pigliacelli, Claudia

AU - Maiolo, Daniele

AU - Nonappa, Nonappa

AU - Haataja, Johannes

AU - Amenitsch, Heinz

AU - Michelet, Claire

AU - Sanchez Moreno, Paola

AU - Tirotta, Ilaria

AU - Metrangolo, Pierangelo

AU - Baldelli Bombelli, Francesca

PY - 2017/12/18

Y1 - 2017/12/18

N2 - Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin HFBII. Our strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport in water of high loadings of partially fluorinated drug molecules.

AB - Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin HFBII. Our strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport in water of high loadings of partially fluorinated drug molecules.

KW - Self-assembly

KW - Supraparticle

KW - Fluorous

KW - Hydrophobin

KW - Gold nanoparticles

U2 - 10.1002/ange.201710230

DO - 10.1002/ange.201710230

M3 - Article

SN - 1433-7851

VL - 129

SP - 16404

EP - 16408

JO - Angewandte Chemie (International Edition)

JF - Angewandte Chemie (International Edition)

IS - 51

ER -

Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Abstract

Keywords

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