Effects of posture on electric fields of non-invasive brain stimulation

Research output: Contribution to journalArticleScientificpeer-review

Standard

Effects of posture on electric fields of non-invasive brain stimulation. / Mikkonen, Marko; Laakso, Ilkka.

In: Physics in Medicine and Biology, Vol. 64, No. 6, 065019, 14.03.2019.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

APA

Vancouver

Author

Bibtex - Download

@article{e0296b9458a84ec58e856ddc8efe15cd,
title = "Effects of posture on electric fields of non-invasive brain stimulation",
abstract = "The brain moves when the orientation of the head changes. This inter-postural motion has been shown to affect the distribution of cerebrospinal fluid (CSF). As CSF layer thickness affects the distribution of electric fields (EF) in non-invasive brain stimulation methods such as transcranial direct current (TDCS) and magnetic (TMS) stimulation, possible differences in body position between sessions could affect the stimulation efficacy. Additionally, inter-postural differences might distort the modeling results of TDCS and TMS, as the models are usually built based on magnetic resonance images (MRI) obtained while the subject is in the supine position, whereas the actual stimulation is given while the subject is in an upright position. Here, we studied the effects of changing the position of the subject between supine, prone, and left lateral on the conformation of the brain. This study aimed to determine whether small inter-postural changes in the shape of the brain can affect TDCS and TMS EFs as hypothesized. We obtained MRI from five subjects in each position and used them to build anatomically realistic models for use in finite element simulations of the EFs. Position was found to affect EFs, with them being approximately 10{\%} stronger and more diffuse while subjects were in the prone and left lateral than in the supine positions for TDCS. In TMS, a similar trend was observed, but the effect was smaller, approximately 2{\%}, than that observed for TDCS. Thus, the effect of posture should be considered in the design of TDCS and TMS experiments.",
keywords = "transcranial magnetic simulation, transcranial direct current stimulation (tDCS), magnetic resonance imaging, posture, brain motion, Transcranial magnetic stimulation, transcranial direct current stimulation, SURFACE-BASED ANALYSIS, TMS STIMULATE, TISSUE, transcranial magnetic stimulation, INDUCED CURRENTS, HUMAN CEREBRAL-CORTEX, TRANSCRANIAL MAGNETIC STIMULATION, MODELS, CONDUCTIVITY, DIELECTRIC-PROPERTIES, MOTOR",
author = "Marko Mikkonen and Ilkka Laakso",
year = "2019",
month = "3",
day = "14",
doi = "10.1088/1361-6560/ab03f5",
language = "English",
volume = "64",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "6",

}

RIS - Download

TY - JOUR

T1 - Effects of posture on electric fields of non-invasive brain stimulation

AU - Mikkonen, Marko

AU - Laakso, Ilkka

PY - 2019/3/14

Y1 - 2019/3/14

N2 - The brain moves when the orientation of the head changes. This inter-postural motion has been shown to affect the distribution of cerebrospinal fluid (CSF). As CSF layer thickness affects the distribution of electric fields (EF) in non-invasive brain stimulation methods such as transcranial direct current (TDCS) and magnetic (TMS) stimulation, possible differences in body position between sessions could affect the stimulation efficacy. Additionally, inter-postural differences might distort the modeling results of TDCS and TMS, as the models are usually built based on magnetic resonance images (MRI) obtained while the subject is in the supine position, whereas the actual stimulation is given while the subject is in an upright position. Here, we studied the effects of changing the position of the subject between supine, prone, and left lateral on the conformation of the brain. This study aimed to determine whether small inter-postural changes in the shape of the brain can affect TDCS and TMS EFs as hypothesized. We obtained MRI from five subjects in each position and used them to build anatomically realistic models for use in finite element simulations of the EFs. Position was found to affect EFs, with them being approximately 10% stronger and more diffuse while subjects were in the prone and left lateral than in the supine positions for TDCS. In TMS, a similar trend was observed, but the effect was smaller, approximately 2%, than that observed for TDCS. Thus, the effect of posture should be considered in the design of TDCS and TMS experiments.

AB - The brain moves when the orientation of the head changes. This inter-postural motion has been shown to affect the distribution of cerebrospinal fluid (CSF). As CSF layer thickness affects the distribution of electric fields (EF) in non-invasive brain stimulation methods such as transcranial direct current (TDCS) and magnetic (TMS) stimulation, possible differences in body position between sessions could affect the stimulation efficacy. Additionally, inter-postural differences might distort the modeling results of TDCS and TMS, as the models are usually built based on magnetic resonance images (MRI) obtained while the subject is in the supine position, whereas the actual stimulation is given while the subject is in an upright position. Here, we studied the effects of changing the position of the subject between supine, prone, and left lateral on the conformation of the brain. This study aimed to determine whether small inter-postural changes in the shape of the brain can affect TDCS and TMS EFs as hypothesized. We obtained MRI from five subjects in each position and used them to build anatomically realistic models for use in finite element simulations of the EFs. Position was found to affect EFs, with them being approximately 10% stronger and more diffuse while subjects were in the prone and left lateral than in the supine positions for TDCS. In TMS, a similar trend was observed, but the effect was smaller, approximately 2%, than that observed for TDCS. Thus, the effect of posture should be considered in the design of TDCS and TMS experiments.

KW - transcranial magnetic simulation

KW - transcranial direct current stimulation (tDCS)

KW - magnetic resonance imaging

KW - posture

KW - brain motion

KW - Transcranial magnetic stimulation

KW - transcranial direct current stimulation

KW - SURFACE-BASED ANALYSIS

KW - TMS STIMULATE

KW - TISSUE

KW - transcranial magnetic stimulation

KW - INDUCED CURRENTS

KW - HUMAN CEREBRAL-CORTEX

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - MODELS

KW - CONDUCTIVITY

KW - DIELECTRIC-PROPERTIES

KW - MOTOR

UR - http://www.scopus.com/inward/record.url?scp=85062986372&partnerID=8YFLogxK

U2 - 10.1088/1361-6560/ab03f5

DO - 10.1088/1361-6560/ab03f5

M3 - Article

VL - 64

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 6

M1 - 065019

ER -

ID: 32803553