Dynamics of DNA Origami Lattices

Sofia Julin, Adrian Keller*, Veikko Linko*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

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Abstract

Hierarchical assembly of programmable DNA frameworks-such as DNA origami-paves the way for versatile nanometer-precise parallel nanopatterning up to macroscopic scales. As of now, the rapid evolution of the DNA nanostructure design techniques and the accessibility of these methods provide a feasible platform for building highly ordered DNA-based assemblies for various purposes. So far, a plethora of different building blocks based on DNA tiles and DNA origami have been introduced, but the dynamics of the large-scale lattice assembly of such modules is still poorly understood. Here, we focus on the dynamics of two-dimensional surface-assisted DNA origami lattice assembly at mica and lipid substrates and the techniques for prospective three-dimensional assemblies, and finally, we summarize the potential applications of such systems.

Original languageEnglish
Pages (from-to)18–29
JournalBioconjugate Chemistry
Volume34
Issue number1
Early online date15 Sep 2022
DOIs
Publication statusPublished - 18 Jan 2023
MoE publication typeA2 Review article in a scientific journal

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