Dynamic optical contrast imaging (DOCI): System theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism

Harrison Cheng*, Yao Xie, Peter Pellionisz, Aidan Pearigen, Khuzaima Rangwalla, Oscar Stafsudd, Zachary Taylor, Maie St John, Warren Grundfest

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

1 Citation (Scopus)
74 Downloads (Pure)

Abstract

Dynamic Optical Contrast Imaging (DOCi) is an imaging technique that generates image contrast through ratiometric measurements of the autouflorescence decay rates of aggregate uorophores in tissue. This method enables better tissue characterization by utilizing wide-field signal integration, eliminating constraints of uniform illumination, and reducing time-intensive computations that are bottlenecks in the clinical translation of traditional fluorescence lifetime imaging. Previous works have demonstrated remarkable tissue contrast between tissue types in clinical human pilot studies [Otolaryngology-Head and Neck Surgery 157, 480 (2017)]. However, there are still challenges in the development of several subsystems, which results in existing works to use relative models. A comprehensive mathematical framework is presented to describe the contrast mechanism of the DOCi system to allow intraoperative quantitative imaging, which merits consideration for evaluation in measuring tissue characteristics in several important clinical settings.

Original languageEnglish
Title of host publicationMedical Imaging 2019
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Cristian A. Linte
ISBN (Electronic)9781510625495
DOIs
Publication statusPublished - 1 Jan 2019
MoE publication typeA4 Article in a conference publication
EventSPIE Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling - San Diego, United States
Duration: 17 Feb 201919 Feb 2019

Publication series

NameProceedings of SPIE
Volume10951
ISSN (Print)1605-7422

Conference

ConferenceSPIE Medical Imaging
CountryUnited States
CitySan Diego
Period17/02/201919/02/2019

Keywords

  • Dynamic Optical Contrast Imaging
  • Fluorescence Lifetime
  • Real-time Imaging
  • SPIE Proceedings
  • System Theory

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    Cheng, H., Xie, Y., Pellionisz, P., Pearigen, A., Rangwalla, K., Stafsudd, O., ... Grundfest, W. (2019). Dynamic optical contrast imaging (DOCI): System theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism. In B. Fei, & C. A. Linte (Eds.), Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling [109512T] (Proceedings of SPIE; Vol. 10951). https://doi.org/10.1117/12.2513823