Dual-light photodynamic therapy effectively eliminates Streptococcus oralis biofilms

Jessica Hentilä; Noora Laakamaa; Timo Sorsa; Jukka Meurman; Hanna Välimaa; Sakari Nikinmaa; Esko Kankuri; Tuomas Tauriainen; Tommi Pätilä

doi:10.18433/jpps32084

Dual-light photodynamic therapy effectively eliminates Streptococcus oralis biofilms

Jessica Hentilä^*, Noora Laakamaa, Timo Sorsa, Jukka Meurman, Hanna Välimaa, Sakari Nikinmaa, Esko Kankuri, Tuomas Tauriainen, Tommi Pätilä

^*Corresponding author for this work

Department of Neuroscience and Biomedical Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

5 Citations (Scopus)

83 Downloads (Pure)

Abstract

Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.

Original language	English
Pages (from-to)	484-487
Number of pages	4
Journal	Journal of Pharmacy and Pharmaceutical Sciences
Volume	24
DOIs	https://doi.org/10.18433/jpps32084
Publication status	Published - 22 Sept 2021
MoE publication type	A1 Journal article-refereed

Keywords

dual-light therapy
photodynamic therapy
Streptococcus oralis
soft-tissue infections
alternative antimicrobial therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18433/jpps32084

Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis BiofilmsFinal published version, 286 KBLicence: CC BY-SA

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title = "Dual-light photodynamic therapy effectively eliminates Streptococcus oralis biofilms",

abstract = "Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.",

keywords = "dual-light therapy, photodynamic therapy, Streptococcus oralis, soft-tissue infections, alternative antimicrobial therapy",

author = "Jessica Hentil{\"a} and Noora Laakamaa and Timo Sorsa and Jukka Meurman and Hanna V{\"a}limaa and Sakari Nikinmaa and Esko Kankuri and Tuomas Tauriainen and Tommi P{\"a}til{\"a}",

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year = "2021",

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doi = "10.18433/jpps32084",

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TY - JOUR

T1 - Dual-light photodynamic therapy effectively eliminates Streptococcus oralis biofilms

AU - Hentilä, Jessica

AU - Laakamaa, Noora

AU - Sorsa, Timo

AU - Meurman, Jukka

AU - Välimaa, Hanna

AU - Nikinmaa, Sakari

AU - Kankuri, Esko

AU - Tauriainen, Tuomas

AU - Pätilä, Tommi

PY - 2021/9/22

Y1 - 2021/9/22

N2 - Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.

AB - Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.

KW - dual-light therapy

KW - photodynamic therapy

KW - Streptococcus oralis

KW - soft-tissue infections

KW - alternative antimicrobial therapy

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U2 - 10.18433/jpps32084

DO - 10.18433/jpps32084

M3 - Article

AN - SCOPUS:85116857829

SN - 1482-1826

VL - 24

SP - 484

EP - 487

JO - Journal of Pharmacy and Pharmaceutical Sciences

JF - Journal of Pharmacy and Pharmaceutical Sciences

ER -

Dual-light photodynamic therapy effectively eliminates Streptococcus oralis biofilms

Abstract

Keywords

UN SDGs

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