DrugE-rank: Predicting drug-target interactions by learning to rank

Jieyao Deng, Qingjun Yuan, Hiroshi Mamitsuka, Shanfeng Zhu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

3 Citations (Scopus)

Abstract

Identifying drug-target interactions is crucial for the success of drug discovery. Approaches based on machine learning for this problem can be divided into two types: feature-based and similarity-based methods. By utilizing the “Learning to rank” framework, we propose a new method, DrugE-Rank, to combine these two different types of methods for improving the prediction performance of new candidate drugs and targets. DrugE-Rank is available at http://datamining-iip.fudan.edu.cn/service/DrugE-Rank/.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherSpringer
Pages195-202
Number of pages8
ISBN (Electronic)978-1-4939-8561-6
ISBN (Print)978-1-4939-8560-9
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA3 Book section, Chapters in research books

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume1807
ISSN (Print)1064-3745

Keywords

  • Drug discovery
  • DrugE-rank
  • Learning to rank

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