Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels

Hanna Valo, Suvi Arola, Päivi Laaksonen, Mika Torkkeli, Leena Peltonen, Markus B. Linder, Ritva Serimaa, Shigenori Kuga, Jouni Hirvonen, Timo Laaksonen*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Highly porous nanocellulose aerogels prepared by freeze-drying from Various nanofibrillar cellulose (NFC) hydrogels are introduced as nanoparticle reservoirs for oral drug delivery systems. Here we show that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated into the NFC aerogels. NFCs from four different origins are introduced and compared to microcrystalline cellulose (MCC). The nanocellulose aerogel scaffolds made from red pepper (RC) and MCC release the drug immediately, while bacterial cellulose (BC), quince seed (QC) and TEMPO-oxidized birch cellulose-based (TC) aerogels show sustained drug release. Since the release of the drug is controlled by the structure and interactions between the nanoparticles and the cellulose matrix, modulation of the matrix formers enable a control of the drug release rate. These nanocomposite structures can be very useful in many pharmaceutical nanoparticle applications and open up new possibilities as carriers for controlled drug delivery. (C) 2013 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number1
DOIs
Publication statusPublished - 27 Sep 2013
MoE publication typeA1 Journal article-refereed

Keywords

  • Nanoparticles
  • Nanofibrillar cellulose
  • Bacterial cellulose
  • Hydrophobin
  • Aerogel
  • Drug release
  • TEMPO-MEDIATED OXIDATION
  • NATIVE CELLULOSE
  • BACTERIAL CELLULOSE
  • ANTISOLVENT PRECIPITATION
  • 2-PHASE SYSTEMS
  • HYDROPHOBINS
  • PROTEINS
  • SUSPENSIONS
  • FORMULATION
  • TEMPLATES

Cite this