DOMAIN FUNCTION IN TRICHODERMA-REESEI CELLOBIOHYDROLASES

T TEERI*, T REINIKAINEN, L RUOHONEN, TA JONES, JKC KNOWLES

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The filamentous fungus, Trichoderma reesei produces all of the enzymatic activities required for efficient hydrolysis of highly ordered crystalline cellulose. All the principal enzymes involved in cellulose hydrolysis possess two functional domains, one directly involved in catalysis and the other in substrate recognition and binding. The availability of high-resolution three dimensional structures of the two domains allows genetic engineering to be used for detailed structure-function studies of these important enzymes.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalJournal of Biotechnology
Volume24
Issue number2
Publication statusPublished - 15 Jun 1992
MoE publication typeA1 Journal article-refereed
EventInternational Conference on the Industrial Applications of Natural, Modified and Artificial Enzymes - Pisa, Italy
Duration: 23 Sep 199029 Sep 1990

Keywords

  • CELLULASE
  • TRICHODERMA
  • DOMAINS
  • CATALYSIS
  • SUBSTRATE BINDING
  • CELLULOLYTIC SYSTEM
  • LIMITED PROTEOLYSIS
  • ENDOGLUCANASE
  • GENE
  • SYNERGISM
  • SEQUENCE
  • QM-9414
  • ENZYME

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