DNA origami-based nanoribbons: Assembly, length distribution, and twist
Research output: Contribution to journal › Article › Scientific › peer-review
- Technische Universität München
A variety of polymerization methods for the assembly of elongated nanoribbons from rectangular DNA origami structures are investigated. The most efficient method utilizes single-stranded DNA oligonucleotides to bridge an intermolecular scaffold seam between origami monomers. This approach allows the fabrication of origami ribbons with lengths of several micrometers, which can be used for long-range ordered arrangement of proteins. It is quantitatively shown that the length distribution of origami ribbons obtained with this technique follows the theoretical prediction for a simple linear polymerization reaction. The design of flat single layer origami structures with constant crossover spacing inevitably results in local underwinding of the DNA helix, which leads to a global twist of the origami structures that also translates to the nanoribbons.
|Number of pages||6|
|Publication status||Published - 8 Jul 2011|
|MoE publication type||A1 Journal article-refereed|