DNA origami design and implementation: the Romanian map

Laura Ioana Popa, Ana-Maria Dobre, Corina Itcus*, Alexandru Amarioarei, Andrei Paun, Mihaela Paun, Felician Pop, Iris Tusa, Minh-Kha Nguyen, Anton Kuzyk, Eugen Czeizler

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Since its introduction in the early 2000s, DNA origami had a big impact on the development of nanotechnology by gathering numerous applications. During this time, many tools were designed and used to generate arbitrary shapes capable of self-assembly which make this technique more approachable. In this paper, we have created the map of Romania at nanoscale dimensions by using a new open-source software - PERDIX. For this purpose, we used a scaffold strand with a length of 6959 nucleotides and 162 staple strands with a variable length ranging between 20 and 63 nucleotides. All the computational tools that were used in this experiment are open-source and user-friendly.

Original languageEnglish
Pages (from-to)1816-1822
Number of pages7
JournalROMANIAN BIOTECHNOLOGICAL LETTERS
Volume25
Issue number4
DOIs
Publication statusPublished - 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • DNA origami
  • nanotechnology
  • nanostructure
  • DNA Romanian map
  • Perdix visualization
  • FOLDING DNA
  • NANOSCALE
  • SHAPES

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