DNA Microarray Analysis: From Affymetrix CEL Files to Comparative Gene Expression

Sandeep Kumar, Shruti Shandilya, Suman Kapila, Mohit Sharma, Nikhil Agrawal

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

1 Citation (Scopus)

Abstract

Microarray technique is widely used for the rapid detection and comparison of expression of thousands of genes at the same time. For the microarray data analysis, robust and reproducible protocols are being generated day by day. Bioconductor provides several free microarray data analysis packages. The analysis includes the following processes: quality control, normalization, and calculation of differential gene expression. This chapter demonstrates a protocol to find out the differentially expressed genes from the raw data (.CEL files) using the Bioconductor tools.

Original languageEnglish
Title of host publicationComputation in Bioinformatics
Subtitle of host publicationMultidisciplinary Applications
PublisherJohn Wiley & Sons
Pages139-153
Number of pages15
ISBN (Electronic)9781119654803
ISBN (Print)9781119654711
DOIs
Publication statusPublished - 1 Jan 2021
MoE publication typeA3 Book section, Chapters in research books

Keywords

  • bioconductor
  • genes
  • Microarray

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