DNA-based enzyme reactors and systems

Veikko Linko*, Sami Nummelin, Laura Aarnos, Kosti Tapio, J. Jussi Toppari, Mauri A. Kostiainen

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

45 Citations (Scopus)
127 Downloads (Pure)

Abstract

During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways. Moreover, sophisticated DNA structures can be utilized in encapsulating active enzymes and delivering the molecular cargo into cells. In this review, we focus on the latest enzyme systems based on novel DNA nanostructures: enzyme reactors, regulatory devices and carriers that can find uses in various biotechnological and nanomedical applications.

Original languageEnglish
Article number139
Pages (from-to)1-16
JournalNanomaterials
Volume6
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Cascade reactions
  • DNA nanodevice
  • DNA nanotechnology
  • DNA origami
  • DNA sensors
  • Drug-delivery
  • Enzyme
  • Nanomedicine
  • Self-assembly

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