Dissociable roles of cerebral μ-opioid and type 2 dopamine receptors in vicarious pain: A combined PET-fMRI study

Tomi Karjalainen*, Henry K. Karlsson, Juha M. Lahnakoski, Enrico Glerean, Pirjo Nuutila, Iiro P. Jääskeläinen, Riitta Hari, Mikko Sams, Lauri Nummenmaa

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)
89 Downloads (Pure)

Abstract

Neuroimaging studies have shown that seeing others in pain activates brain regions that are involved in first-hand pain, suggesting that shared neuromolecular pathways support processing of first-hand and vicarious pain. We tested whether the dopamine and opioid neurotransmitter systems involved in nociceptive processing also contribute to vicarious pain experience. We used in vivo positron emission tomography to quantify type 2 dopamine and μ-opioid receptor (D2R and MOR, respectively) availabilities in brains of 35 subjects. During functional magnetic resonance imaging, the subjects watched short movie clips depicting persons in painful and painless situations. Painful scenes activated pain-responsive brain regions including anterior insulae, thalamus and secondary somatosensory cortices, as well as posterior superior temporal sulci. MOR availability correlated negatively with the haemodynamic responses during painful scenes in anterior and posterior insulae, thalamus, secondary and primary somatosensory cortices, primary motor cortex, and superior temporal sulci. MOR availability correlated positively with orbitofrontal haemodynamic responses during painful scenes. D2R availability was not correlated with the haemodynamic responses in any brain region. These results suggest that the opioid system contributes to neural processing of vicarious pain, and that interindividual differences in opioidergic system could explain why some individuals react more strongly than others to seeing pain.

Original languageEnglish
Pages (from-to)4257-4266
Number of pages10
JournalCerebral Cortex
Volume27
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017
MoE publication typeA1 Journal article-refereed

Keywords

  • Carfentanil
  • Empathy
  • Neurotransmitters
  • Observed pain
  • Raclopride

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