Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

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Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. / Käpylä, Elli; Sedlačík, Tomáš; Aydogan, Dogu Baran; Viitanen, Jouko; Rypáček, František; Kellomäki, Minna.

In: Materials Science and Engineering C, Vol. 43, 01.10.2014, p. 280-289.

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Käpylä, Elli ; Sedlačík, Tomáš ; Aydogan, Dogu Baran ; Viitanen, Jouko ; Rypáček, František ; Kellomäki, Minna. / Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. In: Materials Science and Engineering C. 2014 ; Vol. 43. pp. 280-289.

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@article{2102206ee34a447996632e452a580d3e,
title = "Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization",
abstract = "The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.",
keywords = "Direct laser writing, Hydrogel, Microfabrication, Poly(ethylene glycol) diacrylate, Polyamino acid, Two-photon polymerization",
author = "Elli K{\"a}pyl{\"a} and Tom{\'a}š Sedlač{\'i}k and Aydogan, {Dogu Baran} and Jouko Viitanen and František Ryp{\'a}ček and Minna Kellom{\"a}ki",
year = "2014",
month = "10",
day = "1",
doi = "10.1016/j.msec.2014.07.027",
language = "English",
volume = "43",
pages = "280--289",
journal = "MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS",
issn = "0928-4931",
publisher = "Elsevier Science B.V.",

}

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TY - JOUR

T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

AU - Käpylä, Elli

AU - Sedlačík, Tomáš

AU - Aydogan, Dogu Baran

AU - Viitanen, Jouko

AU - Rypáček, František

AU - Kellomäki, Minna

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

KW - Direct laser writing

KW - Hydrogel

KW - Microfabrication

KW - Poly(ethylene glycol) diacrylate

KW - Polyamino acid

KW - Two-photon polymerization

UR - http://www.scopus.com/inward/record.url?scp=84904903147&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2014.07.027

DO - 10.1016/j.msec.2014.07.027

M3 - Article

VL - 43

SP - 280

EP - 289

JO - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

JF - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

SN - 0928-4931

ER -

ID: 29135177