Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä; Tomáš Sedlačík; Dogu Baran Aydogan; Jouko Viitanen; František Rypáček; Minna Kellomäki

doi:10.1016/j.msec.2014.07.027

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä^*
, Tomáš Sedlačík
, Dogu Baran Aydogan
, Jouko Viitanen
, František Rypáček
, Minna Kellomäki

^*Corresponding author for this work

Not published at Aalto University

Tampere University of Technology
BioMediTech
Czech Academy of Sciences
VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

44 Citations (Scopus)

Abstract

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

Original language	English
Pages (from-to)	280-289
Number of pages	10
Journal	Materials Science and Engineering C: Materials for Biological Applications
Volume	43
DOIs	https://doi.org/10.1016/j.msec.2014.07.027
Publication status	Published - 1 Oct 2014
MoE publication type	A1 Journal article-refereed

Funding

E.K. was financially supported by the Finnish Cultural Foundation and the Doctoral Program of Tampere University of Technology's President . E.K. and M.K. were also supported by the TEKES (the Finnish Funding Agency for Technology and Innovation) Human Spare Parts project. T.S. and F.R. were supported by Czech Science Foundation (Grant No.: P108/11/1857 ). The authors gratefully acknowledge M.Sc. (Eng.) Taru Karhula for SEM imaging.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Direct laser writing
Hydrogel
Microfabrication
Poly(ethylene glycol) diacrylate
Polyamino acid
Two-photon polymerization

Access to Document

10.1016/j.msec.2014.07.027

Cite this

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title = "Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization",

abstract = "The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.",

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doi = "10.1016/j.msec.2014.07.027",

language = "English",

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journal = "Materials Science and Engineering C: Materials for Biological Applications",

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Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. / Käpylä, Elli; Sedlačík, Tomáš; Aydogan, Dogu Baran et al.
In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 43, 01.10.2014, p. 280-289.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

AU - Käpylä, Elli

AU - Sedlačík, Tomáš

AU - Aydogan, Dogu Baran

AU - Viitanen, Jouko

AU - Rypáček, František

AU - Kellomäki, Minna

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N2 - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

KW - Direct laser writing

KW - Hydrogel

KW - Microfabrication

KW - Poly(ethylene glycol) diacrylate

KW - Polyamino acid

KW - Two-photon polymerization

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JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

ER -

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Abstract

Funding

UN SDGs

Keywords

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