TY - JOUR
T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization
AU - Käpylä, Elli
AU - Sedlačík, Tomáš
AU - Aydogan, Dogu Baran
AU - Viitanen, Jouko
AU - Rypáček, František
AU - Kellomäki, Minna
PY - 2014/10/1
Y1 - 2014/10/1
N2 - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.
AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.
KW - Direct laser writing
KW - Hydrogel
KW - Microfabrication
KW - Poly(ethylene glycol) diacrylate
KW - Polyamino acid
KW - Two-photon polymerization
UR - http://www.scopus.com/inward/record.url?scp=84904903147&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2014.07.027
DO - 10.1016/j.msec.2014.07.027
M3 - Article
C2 - 25175215
AN - SCOPUS:84904903147
SN - 0928-4931
VL - 43
SP - 280
EP - 289
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -