Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä*, Tomáš Sedlačík, Dogu Baran Aydogan, Jouko Viitanen, František Rypáček, Minna Kellomäki

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)

Abstract

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

Original languageEnglish
Pages (from-to)280-289
Number of pages10
JournalMaterials Science and Engineering C
Volume43
DOIs
Publication statusPublished - 1 Oct 2014
MoE publication typeA1 Journal article-refereed

Keywords

  • Direct laser writing
  • Hydrogel
  • Microfabrication
  • Poly(ethylene glycol) diacrylate
  • Polyamino acid
  • Two-photon polymerization

Fingerprint Dive into the research topics of 'Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization'. Together they form a unique fingerprint.

Cite this