Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Rubina Ajdary, Guillermo Reyes Torres, Jani Kuula, Eija Raussi-Lehto, Tomi S. Mikkola, Esko Kankuri, Orlando Rojas Gaona*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.
Original languageEnglish
Pages (from-to)97–107
Number of pages11
JournalACS Polymers Au
Volume2
Issue number2
Early online date10 Dec 2021
DOIs
Publication statusPublished - 13 Apr 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • Nanocellulose
  • Chitosan
  • Layer-by-layer meshes
  • Direct ink writing
  • Medical implants

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