Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Rubina Ajdary; Guillermo Reyes Torres; Jani Kuula; Eija Raussi-Lehto; Tomi S. Mikkola; Esko Kankuri; Orlando Rojas Gaona

doi:10.1021/acspolymersau.1c00045

Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Rubina Ajdary, Guillermo Reyes Torres, Jani Kuula, Eija Raussi-Lehto, Tomi S. Mikkola, Esko Kankuri, Orlando Rojas Gaona^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

Original language	English
Pages (from-to)	97–107
Number of pages	11
Journal	ACS Polymers Au
Volume	2
Issue number	2
Early online date	10 Dec 2021
DOIs	https://doi.org/10.1021/acspolymersau.1c00045
Publication status	Published - 13 Apr 2022
MoE publication type	A1 Journal article-refereed

Keywords

Nanocellulose
Chitosan
Layer-by-layer meshes
Direct ink writing
Medical implants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acspolymersau.1c00045Licence: CC BY-NC-ND

CHEM_Ajdary_et_al_Direct_Ink_Writing_2022_ACS_Polymers_AuFinal published version, 11.5 MBLicence: CC BY-NC-ND

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Solving the Mesh
Nieminen, H.
01/02/2020 → 30/09/2022
Project: Business Finland: New business from research ideas (TUTLI)
BioELCell: Bioproducts Engineered from Lignocelluloses: from plants and upcycling to next generation materials
Rojas Gaona, O., Abidnejad, R., Ajdary, R., Bhattarai, M., Zhu, Y., Zhao, B., Robertson, D., Reyes Torres, G., Johansson, L., Garcia Greca, L., Klockars, K., Kämäräinen, T., Majoinen, J., Tardy, B., Dufau Mattos, B. & Ressouche, E.
30/07/2018 → 31/07/2023
Project: EU: ERC grants

OtaNano
Anna Rissanen (Manager)
Aalto University
Facility/equipment: Facility
OtaNano - Nanomicroscopy Center
Jani Seitsonen (Manager)
OtaNano
Facility/equipment: Facility

Cite this

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title = "Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices",

abstract = "Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.",

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AU - Ajdary, Rubina

AU - Reyes Torres, Guillermo

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AU - Raussi-Lehto, Eija

AU - Mikkola, Tomi S.

AU - Kankuri, Esko

AU - Rojas Gaona, Orlando

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KW - Chitosan

KW - Layer-by-layer meshes

KW - Direct ink writing

KW - Medical implants

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Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Abstract

Keywords

UN SDGs

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Projects

Solving the Mesh

BioELCell: Bioproducts Engineered from Lignocelluloses: from plants and upcycling to next generation materials

Equipment

OtaNano

OtaNano - Nanomicroscopy Center

Cite this