Diagnostic accuracy of a novel method for detection of acute transmural myocardial ischemia based upon a self-applicable 3-lead configuration

Milad El Haddad, Delphine Vervloet, Yves Taeymans, Marc De Buyzere, Thierry Bové, Roland Stroobandt, Mattias Duytschaever, Jaakko Malmivuo, Peter Gheeraert*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Background Delayed medical attendance is a leading cause of death in patients with ST elevation myocardial infarction (STEMI). Methods We aimed to introduce, develop, and validate a novel method (RELF method) for detection of transmural ischemia based on a new and easy-to-use 3-lead configuration and orthonormalization of ST reference vectors (STDVN). The study included 60 patients undergoing coronary artery occlusion (CAO) during balloon inflation and 30 healthy subjects. Results STDVN was significantly different and an optimal discriminator between CAO patients and healthy subjects (respectively 8.00 ± 4.50 vs. 1.90 ± 0.86 normalized units, p <0.001). Compared to the 12-lead ECG, the RELF method was sensitive (90 vs. 73%, p = 0.13) and more specific (91 vs. 75%, p <0.001). Conclusions The RELF method is highly accurate for early detection of acute occlusion related ischemia and it outperforms the conventional 12-lead ECG criteria for STEMI. This method provides a platform for self-detection of CAO with handheld devices or smart phones.

Original languageEnglish
Pages (from-to)192-201
Number of pages10
JournalJournal of Electrocardiology
Volume49
Issue number2
DOIs
Publication statusPublished - 1 Mar 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • Diagnosis
  • Electrocardiography
  • Heart arrest
  • Myocardial infarction

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