Background Delayed medical attendance is a leading cause of death in patients with ST elevation myocardial infarction (STEMI). Methods We aimed to introduce, develop, and validate a novel method (RELF method) for detection of transmural ischemia based on a new and easy-to-use 3-lead configuration and orthonormalization of ST reference vectors (STDVN). The study included 60 patients undergoing coronary artery occlusion (CAO) during balloon inflation and 30 healthy subjects. Results STDVN was significantly different and an optimal discriminator between CAO patients and healthy subjects (respectively 8.00 ± 4.50 vs. 1.90 ± 0.86 normalized units, p <0.001). Compared to the 12-lead ECG, the RELF method was sensitive (90 vs. 73%, p = 0.13) and more specific (91 vs. 75%, p <0.001). Conclusions The RELF method is highly accurate for early detection of acute occlusion related ischemia and it outperforms the conventional 12-lead ECG criteria for STEMI. This method provides a platform for self-detection of CAO with handheld devices or smart phones.
|Number of pages||10|
|Journal||Journal of Electrocardiology|
|Publication status||Published - 1 Mar 2016|
|MoE publication type||A1 Journal article-refereed|
- Heart arrest
- Myocardial infarction