Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties

Research output: Contribution to journalArticleScientificpeer-review

Standard

Development of β-TCP-Ti6Al4V structures : Driving cellular response by modulating physical and chemical properties. / Costa, M. M.; Lima, R.; Melo-Fonseca, F.; Bartolomeu, F.; Alves, N.; Miranda, A.; Gasik, M.; Silva, F. S.; Silva, N. A.; Miranda, G.

In: Materials Science and Engineering C, Vol. 98, 01.05.2019, p. 705-716.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Costa, MM, Lima, R, Melo-Fonseca, F, Bartolomeu, F, Alves, N, Miranda, A, Gasik, M, Silva, FS, Silva, NA & Miranda, G 2019, 'Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties' Materials Science and Engineering C, vol. 98, pp. 705-716. https://doi.org/10.1016/j.msec.2019.01.016

APA

Vancouver

Author

Costa, M. M. ; Lima, R. ; Melo-Fonseca, F. ; Bartolomeu, F. ; Alves, N. ; Miranda, A. ; Gasik, M. ; Silva, F. S. ; Silva, N. A. ; Miranda, G. / Development of β-TCP-Ti6Al4V structures : Driving cellular response by modulating physical and chemical properties. In: Materials Science and Engineering C. 2019 ; Vol. 98. pp. 705-716.

Bibtex - Download

@article{d464f28367764d61a40f6daab576cbc2,
title = "Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties",
abstract = "Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In this sense, the produced structures were characterized regarding roughness, wettability, β-TCP quantity and quality inside the structures after fabrication and the pH measured during cell culture (as consequence of β-TCP dissolution) and those aspects were correlated with cellular viability, distribution, morphology and proliferation. These structures displayed a hydrophilic behavior and results showed that the addition of β-TCP to these cellular structures led to an alkalization of the medium, aspect that significantly influences the cellular response. Higher impregnation ratios were found more adequate for lowering the media pH and toxicity, and thus enhance cell adhesion and proliferation.",
keywords = "Multi-material cellular structures, Press and Sintering, Selective Laser Melting, Ti6Al4V, β-Tricalcium Phosphate",
author = "Costa, {M. M.} and R. Lima and F. Melo-Fonseca and F. Bartolomeu and N. Alves and A. Miranda and M. Gasik and Silva, {F. S.} and Silva, {N. A.} and G. Miranda",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.msec.2019.01.016",
language = "English",
volume = "98",
pages = "705--716",
journal = "MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS",
issn = "0928-4931",
publisher = "Elsevier Science B.V.",

}

RIS - Download

TY - JOUR

T1 - Development of β-TCP-Ti6Al4V structures

T2 - Driving cellular response by modulating physical and chemical properties

AU - Costa, M. M.

AU - Lima, R.

AU - Melo-Fonseca, F.

AU - Bartolomeu, F.

AU - Alves, N.

AU - Miranda, A.

AU - Gasik, M.

AU - Silva, F. S.

AU - Silva, N. A.

AU - Miranda, G.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In this sense, the produced structures were characterized regarding roughness, wettability, β-TCP quantity and quality inside the structures after fabrication and the pH measured during cell culture (as consequence of β-TCP dissolution) and those aspects were correlated with cellular viability, distribution, morphology and proliferation. These structures displayed a hydrophilic behavior and results showed that the addition of β-TCP to these cellular structures led to an alkalization of the medium, aspect that significantly influences the cellular response. Higher impregnation ratios were found more adequate for lowering the media pH and toxicity, and thus enhance cell adhesion and proliferation.

AB - Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In this sense, the produced structures were characterized regarding roughness, wettability, β-TCP quantity and quality inside the structures after fabrication and the pH measured during cell culture (as consequence of β-TCP dissolution) and those aspects were correlated with cellular viability, distribution, morphology and proliferation. These structures displayed a hydrophilic behavior and results showed that the addition of β-TCP to these cellular structures led to an alkalization of the medium, aspect that significantly influences the cellular response. Higher impregnation ratios were found more adequate for lowering the media pH and toxicity, and thus enhance cell adhesion and proliferation.

KW - Multi-material cellular structures

KW - Press and Sintering

KW - Selective Laser Melting

KW - Ti6Al4V

KW - β-Tricalcium Phosphate

UR - http://www.scopus.com/inward/record.url?scp=85059872382&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2019.01.016

DO - 10.1016/j.msec.2019.01.016

M3 - Article

VL - 98

SP - 705

EP - 716

JO - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

JF - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

SN - 0928-4931

ER -

ID: 31662519