Development of a Sensing Array for Human Breath Analysis Based on SWCNT Layers Functionalized with Semiconductor Organic Molecules

Sonia Freddi, Aleksei V. Emelianov, Ivan I. Bobrinetskiy, Giovanni Drera, Stefania Pagliara, Daria S. Kopylova, Maria Chiesa, Giuseppe Santini, Nadia Mores, Umberto Moscato, Albert G. Nasibulin, Paolo Montuschi*, Luigi Sangaletti*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)
3 Downloads (Pure)

Abstract

A sensor array based on heterojunctions between semiconducting organic layers and single walled carbon nanotube (SWCNT) films is produced to explore applications in breathomics, the molecular analysis of exhaled breath. The array is exposed to gas/volatiles relevant to specific diseases (ammonia, ethanol, acetone, 2-propanol, sodium hypochlorite, benzene, hydrogen sulfide, and nitrogen dioxide). Then, to evaluate its capability to operate with real relevant biological samples the array is exposed to human breath exhaled from healthy subjects. Finally, to provide a proof of concept of its diagnostic potential, the array is exposed to exhaled breath samples collected from subjects with chronic obstructive pulmonary disease (COPD), an airway chronic inflammatory disease not yet investigated with CNT-based sensor arrays, and breathprints are compared with those obtained from of healthy subjects. Principal component analysis shows that the sensor array is able to detect various target gas/volatiles with a clear fingerprint on a 2D subspace, is suitable for breath profiling in exhaled human breath, and is able to distinguish subjects with COPD from healthy subjects based on their breathprints. This classification ability is further improved by selecting the most responsive sensors to nitrogen dioxide, a potential biomarker of COPD.

Original languageEnglish
Article number2000377
Number of pages14
JournalADVANCED HEALTHCARE MATERIALS
Volume9
Issue number12
Early online date6 May 2020
DOIs
Publication statusPublished - 1 Jun 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • breathomics
  • carbon nanotubes
  • chronic obstructive pulmonary disease
  • electronic noses
  • hybrid heterojunctions
  • WALLED CARBON NANOTUBES
  • ELECTRONIC NOSE
  • LUNG-CANCER
  • GAS SENSORS
  • RESISTIVE SENSORS
  • VOC
  • BIOMARKERS
  • DISCRIMINATION
  • AMMONIA
  • OXIDE

Cite this