Detrended fluctuation analysis in the presurgical evaluation of parietal lobe epilepsy patients

Sami Auno*, Leena Lauronen, Juha Wilenius, Maria Peltola, Sampsa Vanhatalo, J. Matias Palva

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Objective: To examine the usability of long-range temporal correlations (LRTCs) in non-invasive localization of the epileptogenic zone (EZ) in refractory parietal lobe epilepsy (RPLE) patients. Methods: We analyzed 10 RPLE patients who had presurgical MEG and underwent epilepsy surgery. We quantified LRTCs with detrended fluctuation analysis (DFA) at four frequency bands for 200 cortical regions estimated using individual source models. We correlated individually the DFA maps to the distance from the resection area and from cortical locations of interictal epileptiform discharges (IEDs). Additionally, three clinical experts inspected the DFA maps to visually assess the most likely EZ locations. Results: The DFA maps correlated with the distance to resection area in patients with type II focal cortical dysplasia (FCD) (p<0.05), but not in other etiologies. Similarly, the DFA maps correlated with the IED locations only in the FCD II patients. Visual analysis of the DFA maps showed high interobserver agreement and accuracy in FCD patients in assigning the affected hemisphere and lobe. Conclusions: Aberrant LRTCs correlate with the resection areas and IED locations. Significance: This methodological pilot study demonstrates the feasibility of approximating cortical LRTCs from MEG that may aid in the EZ localization and provide new non-invasive insight into the presurgical evaluation of epilepsy.

Original languageEnglish
Pages (from-to)1515-1525
Number of pages11
JournalClinical Neurophysiology
Volume132
Issue number7
DOIs
Publication statusPublished - Jul 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • Detrended fluctuation analysis
  • Epilepsy surgery
  • Long-range temporal correlation
  • MEG

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