Detection of 'EEG bursts' in the early preterm EEG: Visual vs. automated detection

Kirsi Palmu*, Sverre Wikström, Eero Hippeläinen, Geraldine Boylan, Lena Hellström-Westas, Sampsa Vanhatalo

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

60 Citations (Scopus)

Abstract

Objective: To describe the characteristics of activity bursts in the early preterm EEG, to assess inter-rater agreement of burst detection by visual inspection, and to determine the performance of an automated burst detector that uses non-linear energy operator (NLEO). Methods: EEG recordings from extremely preterm (n = 12) and very preterm (n = 6) infants were analysed. Three neurophysiologists independently marked bursts in the EEG, the characteristics of bursts were analyzed and inter-rater agreement determined. Unanimous detections were used as the gold standard in estimating the performance of an automated burst detector. In addition, some details of this automated detector were revised in an attempt to improve performance. Results: Overall, inter-rater agreement was 86% for extremely preterm infants and 81% for very preterm infants. In visual markings, bursts had variable lengths (∼1-10 s) and increased amplitudes (and power) throughout the frequency spectrum. Accuracy of the original detection algorithm was 87% and 79% and accuracy of the revised algorithm 93% and 87% for extremely preterm and very preterm babies, respectively. Conclusion: Visual detection of bursts from the early preterm EEG is comparable albeit not identical between raters. The original automated detector underestimates the amount of burst occurrence, but can be readily improved to yield results comparable to visual detection. Further clinical studies are warranted to assess the optimal descriptors of burst detection for monitoring and prognostication. Significance: Validation of a burst detector offers an evidence-based platform for further development of brain monitors in very preterm babies.

Original languageEnglish
Pages (from-to)1015-1022
Number of pages8
JournalClinical Neurophysiology
Volume121
Issue number7
DOIs
Publication statusPublished - 1 Jul 2010
MoE publication typeA1 Journal article-refereed

Keywords

  • Brain monitoring
  • Neonatal EEG
  • Neonatal intensive care unit
  • Premature EEG
  • SAT

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    Palmu, K., Wikström, S., Hippeläinen, E., Boylan, G., Hellström-Westas, L., & Vanhatalo, S. (2010). Detection of 'EEG bursts' in the early preterm EEG: Visual vs. automated detection. Clinical Neurophysiology, 121(7), 1015-1022. https://doi.org/10.1016/j.clinph.2010.02.010