Designing 3D RNA Origami Nanostructures with a Minimum Number of Kissing Loops

Antti Elonen*, Pekka Orponen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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Abstract

We present a general design technique for rendering any 3D wireframe model, that is any connected graph linearly embedded in 3D space, as an RNA origami nanostructure with a minimum number of kissing loops. The design algorithm, which applies some ideas and methods from topological graph theory, produces renderings that contain at most one kissing-loop pair for many interesting model families, including for instance all fully triangulated wireframes and the wireframes of all Platonic solids. The design method is already implemented and available for use in the design tool DNAforge (https://dnaforge.org).

Original languageEnglish
Title of host publication30th International Conference on DNA Computing and Molecular Programming, DNA 30 2024
EditorsShinnosuke Seki, Jaimie Marie Stewart
PublisherSchloss Dagstuhl - Leibniz-Zentrum für Informatik
Pages1-12
Number of pages12
ISBN (Electronic)978-3-95977-344-7
DOIs
Publication statusPublished - Sept 2024
MoE publication typeA4 Conference publication
EventInternational Conference on DNA Computing and Molecular Programming - Baltimore, United States
Duration: 16 Sept 202420 Sept 2024
Conference number: 30

Publication series

NameLeibniz International Proceedings in Informatics, LIPIcs
PublisherSchloss Dagstuhl - Leibniz-Zentrum für Informatik
Volume314
ISSN (Print)1868-8969

Conference

ConferenceInternational Conference on DNA Computing and Molecular Programming
Abbreviated titleDNA
Country/TerritoryUnited States
CityBaltimore
Period16/09/202420/09/2024

Keywords

  • kissing loops
  • polyhedra
  • RNA origami
  • self-assembly
  • topological graph embeddings
  • wireframe nanostructures

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