Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors
Research output: Contribution to journal › Article
- National Research Center
- Mansoura University
- Digital Bio Pharm Ltd.
- Lomonosov Moscow State University
As a part of a directed program for development of new active agents, novel heterocyclic derivatives with antipyrine and pyrazolone moieties -incorporated in- have been designed and synthesized. Starting with 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivative 2a,b novel Mannich bases derivatives have been synthesized and biologically evaluated for their anti-inflammatory activity. Furthermore, the activity of such compounds has been tested interestingly as COX-1 and COX-2 inhibitors. Structure elucidation of the synthesized compounds was attained by the use of elemental analysis, IR, 1H NMR, 13C NMR, and Mass spectrometry techniques. Compounds 3b, 3d and 4b represent the high % inhibition values for both COX-1 and COX-2. On the other hand, compound 8 showed little selectivity against COX-2 while compound 10 showed good selectivity against COX-1 only. Structure activity relationship has been discussed and the results were confirmed by molecular docking calculations.
|Number of pages||6|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|Publication status||Published - 1 Mar 2018|
|MoE publication type||A1 Journal article-refereed|
- Anti-inflammatory activity, Antipyrine, COX-1, COX-2, Molecular modeling, Pyrazolone derivatives, Synthesis