Deriving stereocilia displacement from the impedance of the organ of Corti

Alessandro Altoè, Ville Pulkki

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

The response of an inner hair cell (IHC) to a sound stimulus varies in terms of phase and harmonic content depending nonlinearly on the stimulus level. This dependency can be explained by the two factor cancellation hypothesis: two excitatory components of the opposite sign, C1 and C2, regulate the IHC receptor potential. However, it is yet unknown whether C1 and C2 represent the contribution of different stereocilia rows to the transduction of a single IHC, or whether they represent different mechanical contributions to the displacement of a single stereocilia bundle. There are also diverse theories about the physical origin of the two components. This work presents a computational model of IHCs functionality having clear physical origins for C1 and C2. In the present model C1 represents the transduction component associated with the coupling between the stereocilia and the basilar membrane (BM), while C2 represents the transduction component associated with the coupling between the stereocilia and the outer hair cells (OHCs). C1 and C2 are derived from the nonlinear cochlear model by Verhulst et al. (2012). In particular, C1 is derived from the BM velocity vector and C2 is derived from the term representing the action of the organ of Corti (OC) on BM motion. The present model is capable to simulate the dynamic response of IHCs and to emulate the dependency of the phase and harmonic content of IHCs response, being in good agreement with animal data. Furthermore, this work introduces a simple physical interpretation of C2 to phenomenological models of two-factor cancellation.

Original languageEnglish
Title of host publicationMechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing
PublisherAmerican Institute of Physics
ISBN (Electronic)9780735413504
DOIs
Publication statusPublished - 31 Dec 2015
MoE publication typeA4 Article in a conference publication
EventInternational Workshop on the Mechanics of Hearing - Cape Sounio, Greece
Duration: 23 Jun 201429 Jun 2014
Conference number: 12

Publication series

NameAIP Conference Proceedings
PublisherAmerican Institute of Physics
Volume1703

Workshop

WorkshopInternational Workshop on the Mechanics of Hearing
Abbreviated titleMoH
CountryGreece
CityCape Sounio
Period23/06/201429/06/2014

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    Altoè, A., & Pulkki, V. (2015). Deriving stereocilia displacement from the impedance of the organ of Corti. In Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing [030013] (AIP Conference Proceedings; Vol. 1703). American Institute of Physics. https://doi.org/10.1063/1.4939328