Depression, depressive symptoms and treatments in women who have recently given birth: UK cohort study

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Depression, depressive symptoms and treatments in women who have recently given birth : UK cohort study. / Petersen, Irene; Peltola, Tomi; Kaski, Samuel; Walters, Kate R; Hardoon, Sarah.

In: BMJ Open, Vol. 8, No. 10, e02215, 24.10.2018, p. 1-8.

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@article{ef161b00222c42f7b60f2c5a4de72679,
title = "Depression, depressive symptoms and treatments in women who have recently given birth: UK cohort study",
abstract = "Objectives: To investigate how depression is recognised in the year after child birth and treatment given in clinical practice. Design: Cohort study based on UK primary care electronic health records. Setting: Primary care. Participants: Women who have given live birth between 2000 and 2013. Outcomes: Prevalence of postnatal depression, depression diagnoses, depressive symptoms, antidepressant and non-pharmacological treatment within a year after birth. Results: Of 206 517 women, 23 623 (11{\%}) had a record of depressive diagnosis or symptoms in the year after delivery and more than one in eight women received antidepressant treatment. Recording and treatment peaked 6-8 weeks after delivery. Initiation of selective serotonin reuptake inhibitors (SSRI) treatment has become earlier in the more recent years. Thus, the initiation rate of SSRI treatment per 100 pregnancies (95{\%} CI) at 8 weeks were 2.6 (2.5 to 2.8) in 2000-2004, increasing to 3.0 (2.9 to 3.1) in 2005-2009 and 3.8 (3.6 to 3.9) in 2010-2013. The overall rate of initiation of SSRI within the year after delivery, however, has not changed noticeably. A third of the women had at least one record suggestive of depression at any time prior to delivery and of these one in four received SSRI treatment in the year after delivery. Younger women were most likely to have records of depression and depressive symptoms. (Relative risk for postnatal depression: age 15-19: 1.92 (1.76 to 2.10), age 20-24: 1.49 (1.39 to 1.59) versus age 30-34). The risk of depression, postnatal depression and depressive symptoms increased with increasing social deprivation. Conclusions: More than 1 in 10 women had electronic health records indicating depression diagnoses or depressive symptoms within a year after delivery and more than one in eight women received antidepressant treatment in this period. Women aged below 30 and from the most deprived areas were at highest risk of depression and most likely to receive antidepressant treatment.",
keywords = "non-pharmacological treatment, Postnatal depression, primary care, ssri treatment",
author = "Irene Petersen and Tomi Peltola and Samuel Kaski and Walters, {Kate R} and Sarah Hardoon",
year = "2018",
month = "10",
day = "24",
doi = "10.1136/bmjopen-2018-022152",
language = "English",
volume = "8",
pages = "1--8",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "10",

}

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TY - JOUR

T1 - Depression, depressive symptoms and treatments in women who have recently given birth

T2 - UK cohort study

AU - Petersen, Irene

AU - Peltola, Tomi

AU - Kaski, Samuel

AU - Walters, Kate R

AU - Hardoon, Sarah

PY - 2018/10/24

Y1 - 2018/10/24

N2 - Objectives: To investigate how depression is recognised in the year after child birth and treatment given in clinical practice. Design: Cohort study based on UK primary care electronic health records. Setting: Primary care. Participants: Women who have given live birth between 2000 and 2013. Outcomes: Prevalence of postnatal depression, depression diagnoses, depressive symptoms, antidepressant and non-pharmacological treatment within a year after birth. Results: Of 206 517 women, 23 623 (11%) had a record of depressive diagnosis or symptoms in the year after delivery and more than one in eight women received antidepressant treatment. Recording and treatment peaked 6-8 weeks after delivery. Initiation of selective serotonin reuptake inhibitors (SSRI) treatment has become earlier in the more recent years. Thus, the initiation rate of SSRI treatment per 100 pregnancies (95% CI) at 8 weeks were 2.6 (2.5 to 2.8) in 2000-2004, increasing to 3.0 (2.9 to 3.1) in 2005-2009 and 3.8 (3.6 to 3.9) in 2010-2013. The overall rate of initiation of SSRI within the year after delivery, however, has not changed noticeably. A third of the women had at least one record suggestive of depression at any time prior to delivery and of these one in four received SSRI treatment in the year after delivery. Younger women were most likely to have records of depression and depressive symptoms. (Relative risk for postnatal depression: age 15-19: 1.92 (1.76 to 2.10), age 20-24: 1.49 (1.39 to 1.59) versus age 30-34). The risk of depression, postnatal depression and depressive symptoms increased with increasing social deprivation. Conclusions: More than 1 in 10 women had electronic health records indicating depression diagnoses or depressive symptoms within a year after delivery and more than one in eight women received antidepressant treatment in this period. Women aged below 30 and from the most deprived areas were at highest risk of depression and most likely to receive antidepressant treatment.

AB - Objectives: To investigate how depression is recognised in the year after child birth and treatment given in clinical practice. Design: Cohort study based on UK primary care electronic health records. Setting: Primary care. Participants: Women who have given live birth between 2000 and 2013. Outcomes: Prevalence of postnatal depression, depression diagnoses, depressive symptoms, antidepressant and non-pharmacological treatment within a year after birth. Results: Of 206 517 women, 23 623 (11%) had a record of depressive diagnosis or symptoms in the year after delivery and more than one in eight women received antidepressant treatment. Recording and treatment peaked 6-8 weeks after delivery. Initiation of selective serotonin reuptake inhibitors (SSRI) treatment has become earlier in the more recent years. Thus, the initiation rate of SSRI treatment per 100 pregnancies (95% CI) at 8 weeks were 2.6 (2.5 to 2.8) in 2000-2004, increasing to 3.0 (2.9 to 3.1) in 2005-2009 and 3.8 (3.6 to 3.9) in 2010-2013. The overall rate of initiation of SSRI within the year after delivery, however, has not changed noticeably. A third of the women had at least one record suggestive of depression at any time prior to delivery and of these one in four received SSRI treatment in the year after delivery. Younger women were most likely to have records of depression and depressive symptoms. (Relative risk for postnatal depression: age 15-19: 1.92 (1.76 to 2.10), age 20-24: 1.49 (1.39 to 1.59) versus age 30-34). The risk of depression, postnatal depression and depressive symptoms increased with increasing social deprivation. Conclusions: More than 1 in 10 women had electronic health records indicating depression diagnoses or depressive symptoms within a year after delivery and more than one in eight women received antidepressant treatment in this period. Women aged below 30 and from the most deprived areas were at highest risk of depression and most likely to receive antidepressant treatment.

KW - non-pharmacological treatment

KW - Postnatal depression

KW - primary care

KW - ssri treatment

UR - http://dx.doi.org/10.1136/bmjopen-2018-022152

U2 - 10.1136/bmjopen-2018-022152

DO - 10.1136/bmjopen-2018-022152

M3 - Article

VL - 8

SP - 1

EP - 8

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 10

M1 - e02215

ER -

ID: 28939930