Delineating insight-processing-related functional activations in the precuneus in first-episode psychosis patients

Teemu Mäntylä*, Tuula Kieseppä, Jaana Suvisaari, Tuukka T. Raij

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

8 Downloads (Pure)

Abstract

Poor insight is a central characteristic of psychotic disorders, and it has been suggested to result from a general dysfunction in self-reflection. However, brain processing of clinical insight and more general self-reflection has not been directly compared. We compared tasks on (1) self-reflection on psychosis-related mental functioning (clinical insight, in patients only), (2) self-reflection on mental functioning unrelated to psychosis (general metacognition), and (3) semantic control during blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging with 19 first-episode psychosis patients and 24 control participants. Arterial-spin-labeling (ASL) images were collected at rest. Clinical insight was evaluated with the Schedule for the Assessment of Insight. In patients, posterosuperior precuneus showed stronger activation during the insight task than during the semantic control task, while anteroinferior precuneus and posterior cingulate cortex (PCC) showed stronger activation during the insight task than during the general metacognition task. No significant group differences in brain activation emerged during the general metacognition task. Although the BOLD measures did not correlate with clinical insight measures, ASL-measured cerebral blood flow (CBF) values did correlate when extracted from the task-selective precuneus/PCC areas: higher CBF correlated with higher clinical insight scores. These results suggest that regions in the posteromedial cortex are selective for clinical insight.

Original languageEnglish
Article number111347
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume317
DOIs
Publication statusPublished - 30 Nov 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • Arterial spin labeling
  • First-episode psychosis
  • Functional magnetic resonance imaging
  • Insight
  • Posterior cingulate cortex
  • Precuneus
  • Schizophrenia

Fingerprint

Dive into the research topics of 'Delineating insight-processing-related functional activations in the precuneus in first-episode psychosis patients'. Together they form a unique fingerprint.

Cite this