Deep Learning Fundus Image Analysis for Diabetic Retinopathy and Macular Edema Grading

Jaakko Sahlsten, Joel Jaskari, Jyri Kivinen, Lauri Turunen, Esa Jaanio, Kustaa Hietala, Kimmo Kaski*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

142 Citations (Scopus)
297 Downloads (Pure)


Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening and diagnosis. This labor-intensive task could greatly benefit from automatic detection using deep learning technique. Here we present a deep learning system that identifies referable diabetic retinopathy comparably or better than presented in the previous studies, although we use only a small fraction of images (<1/4) in training but are aided with higher image resolutions. We also provide novel results for five different screening and clinical grading systems for diabetic retinopathy and macular edema classification, including state-of-the-art results for accurately classifying images according to clinical five-grade diabetic retinopathy and for the first time for the four-grade diabetic macular edema scales. These results suggest, that a deep learning system could increase the cost-effectiveness of screening and diagnosis, while attaining higher than recommended performance, and that the system could be applied in clinical examinations requiring finer grading.

Original languageEnglish
Article number10750
Pages (from-to)1-11
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2019
MoE publication typeA1 Journal article-refereed


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