Curdlan in fibers as carriers of tetracycline hydrochloride: Controlled release and antibacterial activity

Mehrez E. El-Naggar*, Abdelrahman M. Abdelgawad, Carlos Salas, Orlando Rojas Gaona

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    52 Citations (Scopus)

    Abstract

    Curdlan (CURD) and polyethylene oxide were used to synthesize nanofibers as carriers of hydro soluble tetracycline hydrochloride (TCH). The viscosity, surface tension and conductivity of the precursor multicomponent aqueous solutions were determined and adjusted to produce defect-free fiber webs. Except for a slight increase in diameter, the addition of TCH did not affect the original morphology of the CURD/PEO nanofibers, as determined by FE-SEM imaging. However, the thermal stability of the system was enhanced (TGA and DSC). Moreover, water resistance, as measured with 24-h immersion tests, was observed upon crosslinking with glutaraldehyde. In-vitro activity measurements indicated a sustained and controlled TCH time-release pattern and excellent antibacterial activity against E. coli, as assessed by UV–vis spectroscopy and viable cell counting, respectively. Overall, we propose nanofibers based on CURD as promising platforms for scaffolds for wound dressing and drug delivery.

    Original languageEnglish
    Pages (from-to)194-203
    Number of pages10
    JournalCarbohydrate Polymers
    Volume154
    DOIs
    Publication statusPublished - 10 Dec 2016
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Antibacterial
    • Curdlan
    • Drug delivery
    • Electrospinning
    • Nanofibers
    • Tetracycline hydrochloride

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