Curdlan cryogels reinforced with cellulose nanofibrils for controlled release

Mehrez E. El-Naggar; Abdelrahman M. Abdelgawad; Anurodh Tripathi; Orlando J. Rojas

doi:10.1016/j.jece.2017.10.056

Curdlan cryogels reinforced with cellulose nanofibrils for controlled release

Mehrez E. El-Naggar^*, Abdelrahman M. Abdelgawad, Anurodh Tripathi, Orlando J. Rojas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

56 Citations (Scopus)

Abstract

Curdlan based cryogels were prepared and tested for their structural and thermal properties by using field emission scanning electron microscopy and thermogravimetric analysis, respectively. Volume shrinkage, mechanical performance, swelling, solubility and density were accessed as a function of composition, which included cellulose nanofibrils (CNF) and polyethylene oxide (PEO). PEO/CURD and PEO/CURD/CNF cryogels exhibited porous and layered structures. The addition of CNF significantly improved the in-vitro release of a nonsteroidal anti-inflammatory drug (diclofenac sodium), which is a promising alternative to current non-biodegradable systems.

Original language	English
Pages (from-to)	5754-5761
Number of pages	8
Journal	Journal of Environmental Chemical Engineering
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/j.jece.2017.10.056
Publication status	Published - 1 Dec 2017
MoE publication type	A1 Journal article-refereed

Keywords

Cellulose nanofibrils
Cryogels
Curdlan
Diclofenac sodium
Drug delivery

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10.1016/j.jece.2017.10.056

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abstract = "Curdlan based cryogels were prepared and tested for their structural and thermal properties by using field emission scanning electron microscopy and thermogravimetric analysis, respectively. Volume shrinkage, mechanical performance, swelling, solubility and density were accessed as a function of composition, which included cellulose nanofibrils (CNF) and polyethylene oxide (PEO). PEO/CURD and PEO/CURD/CNF cryogels exhibited porous and layered structures. The addition of CNF significantly improved the in-vitro release of a nonsteroidal anti-inflammatory drug (diclofenac sodium), which is a promising alternative to current non-biodegradable systems.",

keywords = "Cellulose nanofibrils, Cryogels, Curdlan, Diclofenac sodium, Drug delivery",

author = "El-Naggar, {Mehrez E.} and Abdelgawad, {Abdelrahman M.} and Anurodh Tripathi and Rojas, {Orlando J.}",

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AU - El-Naggar, Mehrez E.

AU - Abdelgawad, Abdelrahman M.

AU - Tripathi, Anurodh

AU - Rojas, Orlando J.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Curdlan based cryogels were prepared and tested for their structural and thermal properties by using field emission scanning electron microscopy and thermogravimetric analysis, respectively. Volume shrinkage, mechanical performance, swelling, solubility and density were accessed as a function of composition, which included cellulose nanofibrils (CNF) and polyethylene oxide (PEO). PEO/CURD and PEO/CURD/CNF cryogels exhibited porous and layered structures. The addition of CNF significantly improved the in-vitro release of a nonsteroidal anti-inflammatory drug (diclofenac sodium), which is a promising alternative to current non-biodegradable systems.

AB - Curdlan based cryogels were prepared and tested for their structural and thermal properties by using field emission scanning electron microscopy and thermogravimetric analysis, respectively. Volume shrinkage, mechanical performance, swelling, solubility and density were accessed as a function of composition, which included cellulose nanofibrils (CNF) and polyethylene oxide (PEO). PEO/CURD and PEO/CURD/CNF cryogels exhibited porous and layered structures. The addition of CNF significantly improved the in-vitro release of a nonsteroidal anti-inflammatory drug (diclofenac sodium), which is a promising alternative to current non-biodegradable systems.

KW - Cellulose nanofibrils

KW - Cryogels

KW - Curdlan

KW - Diclofenac sodium

KW - Drug delivery

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M3 - Article

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EP - 5761

JO - Journal of Environmental Chemical Engineering

JF - Journal of Environmental Chemical Engineering

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ER -

Curdlan cryogels reinforced with cellulose nanofibrils for controlled release

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