Curdlan cryogels reinforced with cellulose nanofibrils for controlled release

Mehrez E. El-Naggar*, Abdelrahman M. Abdelgawad, Anurodh Tripathi, Orlando J. Rojas

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Abstract

Curdlan based cryogels were prepared and tested for their structural and thermal properties by using field emission scanning electron microscopy and thermogravimetric analysis, respectively. Volume shrinkage, mechanical performance, swelling, solubility and density were accessed as a function of composition, which included cellulose nanofibrils (CNF) and polyethylene oxide (PEO). PEO/CURD and PEO/CURD/CNF cryogels exhibited porous and layered structures. The addition of CNF significantly improved the in-vitro release of a nonsteroidal anti-inflammatory drug (diclofenac sodium), which is a promising alternative to current non-biodegradable systems.

Original languageEnglish
Pages (from-to)5754-5761
Number of pages8
JournalJournal of Environmental Chemical Engineering
Volume5
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017
MoE publication typeA1 Journal article-refereed

Keywords

  • Cellulose nanofibrils
  • Cryogels
  • Curdlan
  • Diclofenac sodium
  • Drug delivery

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