Crystallization of glycine with ultrasound

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Crystallization of glycine with ultrasound. / Louhi-Kultanen, Marjatta; Karjalainen, Milja; Rantanen, Jukka; Huhtanen, Mikko; Kallas, Juha.

In: International Journal of Pharmaceutics, Vol. 320, No. 1-2, 31.08.2006, p. 23-29.

Research output: Contribution to journalArticleScientificpeer-review

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Louhi-Kultanen, M, Karjalainen, M, Rantanen, J, Huhtanen, M & Kallas, J 2006, 'Crystallization of glycine with ultrasound' International Journal of Pharmaceutics, vol. 320, no. 1-2, pp. 23-29. https://doi.org/10.1016/j.ijpharm.2006.03.054

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Louhi-Kultanen, Marjatta ; Karjalainen, Milja ; Rantanen, Jukka ; Huhtanen, Mikko ; Kallas, Juha. / Crystallization of glycine with ultrasound. In: International Journal of Pharmaceutics. 2006 ; Vol. 320, No. 1-2. pp. 23-29.

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@article{639398bd725d4c4c8f6f489f4449e2cd,
title = "Crystallization of glycine with ultrasound",
abstract = "Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20 kHz at two temperature ranges 40-50 and 20-30 °C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.",
keywords = "Crystal habit, Crystallization, Particle size, Polymorphism, Ultrasound",
author = "Marjatta Louhi-Kultanen and Milja Karjalainen and Jukka Rantanen and Mikko Huhtanen and Juha Kallas",
year = "2006",
month = "8",
day = "31",
doi = "10.1016/j.ijpharm.2006.03.054",
language = "English",
volume = "320",
pages = "23--29",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS - Download

TY - JOUR

T1 - Crystallization of glycine with ultrasound

AU - Louhi-Kultanen, Marjatta

AU - Karjalainen, Milja

AU - Rantanen, Jukka

AU - Huhtanen, Mikko

AU - Kallas, Juha

PY - 2006/8/31

Y1 - 2006/8/31

N2 - Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20 kHz at two temperature ranges 40-50 and 20-30 °C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.

AB - Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20 kHz at two temperature ranges 40-50 and 20-30 °C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.

KW - Crystal habit

KW - Crystallization

KW - Particle size

KW - Polymorphism

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=33746457314&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2006.03.054

DO - 10.1016/j.ijpharm.2006.03.054

M3 - Article

VL - 320

SP - 23

EP - 29

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 10773218