Crystalline Cyclophane–Protein Cage Frameworks

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Crystalline Cyclophane–Protein Cage Frameworks. / Beyeh, Ngong; Nonappa, Nonappa; Liljeström, Ville; Mikkilä, Joona; Korpi, Antti; Bochicchio, Davide; Pavan, Giovanni M.; Ikkala, Olli; Ras, Robin H. A. ; Kostiainen, Mauri.

In: ACS Nano, Vol. 12, No. 8, 8b02856, 13.07.2018, p. 8029-8036.

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Beyeh, Ngong ; Nonappa, Nonappa ; Liljeström, Ville ; Mikkilä, Joona ; Korpi, Antti ; Bochicchio, Davide ; Pavan, Giovanni M. ; Ikkala, Olli ; Ras, Robin H. A. ; Kostiainen, Mauri. / Crystalline Cyclophane–Protein Cage Frameworks. In: ACS Nano. 2018 ; Vol. 12, No. 8. pp. 8029-8036.

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@article{67de9a058f0c4673a7783fcc0c2bdedb,
title = "Crystalline Cyclophane–Protein Cage Frameworks",
abstract = "Cyclophanes are macrocyclic supramolecular hosts famous for their ability to bind atomic or molecular guests via noncovalent interactions within their well-defined cavities. In a similar way, porous crystalline networks, such as metal–organic frameworks, can create microenvironments that enable controlled guest binding in the solid state. Both types of materials often consist of synthetic components, and they have been developed within separate research fields. Moreover, the use of biomolecules as their structural units has remained elusive. Here, we have synthesized a library of organic cyclophanes and studied their electrostatic self-assembly with biological metal-binding protein cages (ferritins) into ordered structures. We show that cationic pillar[5]arenes and ferritin cages form biohybrid cocrystals with an open protein network structure. Our cyclophane–protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. Such host–guest materials are interesting for porous material applications, including water remediation and heterogeneous catalysis.",
keywords = "protein cage, cyclophane, pillararene, crystal, self-assembly, electrostatic binding",
author = "Ngong Beyeh and Nonappa Nonappa and Ville Liljestr{\"o}m and Joona Mikkil{\"a} and Antti Korpi and Davide Bochicchio and Pavan, {Giovanni M.} and Olli Ikkala and Ras, {Robin H. A.} and Mauri Kostiainen",
year = "2018",
month = "7",
day = "13",
doi = "10.1021/acsnano.8b02856",
language = "English",
volume = "12",
pages = "8029--8036",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "AMERICAN CHEMICAL SOCIETY",
number = "8",

}

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TY - JOUR

T1 - Crystalline Cyclophane–Protein Cage Frameworks

AU - Beyeh, Ngong

AU - Nonappa, Nonappa

AU - Liljeström, Ville

AU - Mikkilä, Joona

AU - Korpi, Antti

AU - Bochicchio, Davide

AU - Pavan, Giovanni M.

AU - Ikkala, Olli

AU - Ras, Robin H. A.

AU - Kostiainen, Mauri

PY - 2018/7/13

Y1 - 2018/7/13

N2 - Cyclophanes are macrocyclic supramolecular hosts famous for their ability to bind atomic or molecular guests via noncovalent interactions within their well-defined cavities. In a similar way, porous crystalline networks, such as metal–organic frameworks, can create microenvironments that enable controlled guest binding in the solid state. Both types of materials often consist of synthetic components, and they have been developed within separate research fields. Moreover, the use of biomolecules as their structural units has remained elusive. Here, we have synthesized a library of organic cyclophanes and studied their electrostatic self-assembly with biological metal-binding protein cages (ferritins) into ordered structures. We show that cationic pillar[5]arenes and ferritin cages form biohybrid cocrystals with an open protein network structure. Our cyclophane–protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. Such host–guest materials are interesting for porous material applications, including water remediation and heterogeneous catalysis.

AB - Cyclophanes are macrocyclic supramolecular hosts famous for their ability to bind atomic or molecular guests via noncovalent interactions within their well-defined cavities. In a similar way, porous crystalline networks, such as metal–organic frameworks, can create microenvironments that enable controlled guest binding in the solid state. Both types of materials often consist of synthetic components, and they have been developed within separate research fields. Moreover, the use of biomolecules as their structural units has remained elusive. Here, we have synthesized a library of organic cyclophanes and studied their electrostatic self-assembly with biological metal-binding protein cages (ferritins) into ordered structures. We show that cationic pillar[5]arenes and ferritin cages form biohybrid cocrystals with an open protein network structure. Our cyclophane–protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. Such host–guest materials are interesting for porous material applications, including water remediation and heterogeneous catalysis.

KW - protein cage

KW - cyclophane

KW - pillararene

KW - crystal

KW - self-assembly

KW - electrostatic binding

UR - http://www.scopus.com/inward/record.url?scp=85050010362&partnerID=8YFLogxK

U2 - 10.1021/acsnano.8b02856

DO - 10.1021/acsnano.8b02856

M3 - Article

VL - 12

SP - 8029

EP - 8036

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 8

M1 - 8b02856

ER -

ID: 27962178