Crosstalk between long noncoding RNA and microRNA in Cancer

Rahul Bhattacharjee; Neeraj Prabhakar; Lamha Kumar; Arkadyuti Bhattacharjee; Sulagna Kar; Sumira Malik; Dhruv Kumar; Janne Ruokolainen; Arvind Negi; Niraj Kumar Jha; Kavindra Kumar Kesari

doi:10.1007/s13402-023-00806-9

Crosstalk between long noncoding RNA and microRNA in Cancer

Rahul Bhattacharjee
, Neeraj Prabhakar
, Lamha Kumar
, Arkadyuti Bhattacharjee
, Sulagna Kar
, Sumira Malik
, Dhruv Kumar
, Janne Ruokolainen
, Arvind Negi^*
, Niraj Kumar Jha^*
, Kavindra Kumar Kesari^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article › peer-review

60 Citations (Scopus)

100 Downloads (Pure)

Abstract

miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	885-908
Number of pages	24
Journal	Cellular Oncology
Volume	46
Issue number	4
Early online date	28 May 2023
DOIs	https://doi.org/10.1007/s13402-023-00806-9
Publication status	Published - Aug 2023
MoE publication type	A2 Review article, Literature review, Systematic review

Funding

We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Cancer
Epithelial-mesenchymal transition
Long-noncoding RNA
Metastasis
MicroRNA
Neovascularization
Vascular mimicry

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10.1007/s13402-023-00806-9Licence: CC BY

Crosstalk between long noncoding RNA and microRNA in CancerFinal published version, 3.33 MBLicence: CC BY

Cite this

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title = "Crosstalk between long noncoding RNA and microRNA in Cancer",

abstract = "miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].",

keywords = "Angiogenesis, Cancer, Epithelial-mesenchymal transition, Long-noncoding RNA, Metastasis, MicroRNA, Neovascularization, Vascular mimicry",

author = "Rahul Bhattacharjee and Neeraj Prabhakar and Lamha Kumar and Arkadyuti Bhattacharjee and Sulagna Kar and Sumira Malik and Dhruv Kumar and Janne Ruokolainen and Arvind Negi and Jha, \{Niraj Kumar\} and Kesari, \{Kavindra Kumar\}",

note = "Funding Information: We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.) Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = aug,

doi = "10.1007/s13402-023-00806-9",

language = "English",

volume = "46",

pages = "885--908",

journal = "Cellular Oncology",

issn = "2211-3428",

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T1 - Crosstalk between long noncoding RNA and microRNA in Cancer

AU - Bhattacharjee, Rahul

AU - Prabhakar, Neeraj

AU - Kumar, Lamha

AU - Bhattacharjee, Arkadyuti

AU - Kar, Sulagna

AU - Malik, Sumira

AU - Kumar, Dhruv

AU - Ruokolainen, Janne

AU - Negi, Arvind

AU - Jha, Niraj Kumar

AU - Kesari, Kavindra Kumar

N1 - Funding Information: We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.) Publisher Copyright: © 2023, The Author(s).

PY - 2023/8

Y1 - 2023/8

N2 - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].

AB - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].

KW - Angiogenesis

KW - Cancer

KW - Epithelial-mesenchymal transition

KW - Long-noncoding RNA

KW - Metastasis

KW - MicroRNA

KW - Neovascularization

KW - Vascular mimicry

UR - https://www.scopus.com/pages/publications/85160413380

U2 - 10.1007/s13402-023-00806-9

DO - 10.1007/s13402-023-00806-9

M3 - Review Article

C2 - 37245177

AN - SCOPUS:85160413380

SN - 2211-3428

VL - 46

SP - 885

EP - 908

JO - Cellular Oncology

JF - Cellular Oncology

IS - 4

ER -

Crosstalk between long noncoding RNA and microRNA in Cancer

Abstract

Funding

UN SDGs

Keywords

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